Comparative evaluation of immune responses and protection of chitosan nanoparticles and oil-emulsion adjuvants in avian coronavirus inactivated vaccines in chickens

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)-
Autor(es): dc.creatorLopes, Priscila Diniz-
Autor(es): dc.creatorOkino, Cintia Hiromi-
Autor(es): dc.creatorFernando, Filipe Santos-
Autor(es): dc.creatorPavani, Caren-
Autor(es): dc.creatorMariguela, Viviane Casagrande-
Autor(es): dc.creatorMontassier, Maria de Fátima Silva-
Autor(es): dc.creatorMontassier, Hélio José-
Data de aceite: dc.date.accessioned2025-08-21T19:46:54Z-
Data de disponibilização: dc.date.available2025-08-21T19:46:54Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/vaccines9121457-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230092-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230092-
Descrição: dc.descriptionEfficient vaccines are the main strategy to control the avian coronavirus (AvCoV), although several drawbacks related to traditional attenuated and inactivated vaccines have been reported. These counterpoints highlight the importance of developing new alternative vaccines against AvCoV, especially those able to induce long-lasting immune responses. This study evaluated and compared two inactivated vaccines formulated with AvCoV BR-I variants, one composed of chitosan nanoparticles (AvCoV-CS) and the second by Montanide oily adjuvant (AvCoV-O). Both developed vaccines were administered in a single dose or associated with the traditional Mass attenuated vaccine. The AvCoV-CS vaccine administered alone or associated with the Mass vaccine was able to induce strong humoral and cell-mediated immune (CMI) responses and complete protection against IBV virulent infection, wherein single administration was characterized by high IgA antibody levels in the mucosa, whereas when associated with the Mass vaccine, the serum IgG antibody was predominantly ob-served. On the other hand, single administration of the oily vaccine presented poor humoral and CMI responses and consequently incomplete protection against virulent challenge, but when associated with the Mass vaccine, immune responses were developed, and complete protection against infection was observed. Both of our experimental vaccines were able to induce full protection against virulent IBV challenge. A single dose of AvCoV-CS vaccine was sufficient to achieve complete protection, while AvCoV-O required a previous priming by a Mass strain to complete the protection.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Veterinary Pathology School of Agricultural and Veterinarian Sciences Jaboticabal São Paulo State University (Unesp)-
Descrição: dc.descriptionEmbrapa Southeast Livestock Brazilian Agricultural Research Corporation (Embrapa), Canchim Farm-
Descrição: dc.descriptionDepartment of Veterinary Pathology School of Agricultural and Veterinarian Sciences Jaboticabal São Paulo State University (Unesp)-
Descrição: dc.descriptionCNPq: 140100/2015-6-
Idioma: dc.languageen-
Relação: dc.relationVaccines-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAvian infectious bronchitis-
Palavras-chave: dc.subjectCellular immune response-
Palavras-chave: dc.subjectDelivery carrier-adjuvant-
Palavras-chave: dc.subjectMucosal immunization-
Palavras-chave: dc.subjectOil adjuvant-
Título: dc.titleComparative evaluation of immune responses and protection of chitosan nanoparticles and oil-emulsion adjuvants in avian coronavirus inactivated vaccines in chickens-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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