Association between frailty and C-terminal agrin fragment with 3-month mortality following ST-elevation myocardial infarction

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorComplexo Hospitalar Santa Genoveva de Uberlândia-
Autor(es): dc.contributorUFG- Univ Federal de Goiás-
Autor(es): dc.contributorUniversity of Leicester-
Autor(es): dc.contributorUniversity of Nottingham-
Autor(es): dc.creatorde Souza Ramos, Juan Thomaz Gabriel-
Autor(es): dc.creatorFerrari, Felipe Sanches-
Autor(es): dc.creatorAndrade, Morganna Freitas-
Autor(es): dc.creatorde Melo, Caroline Souto-
Autor(es): dc.creatorBoas, Paulo José Fortes Villas-
Autor(es): dc.creatorCosta, Nara Aline-
Autor(es): dc.creatorPereira, Amanda Gomes-
Autor(es): dc.creatorDorna, Mariana Souza-
Autor(es): dc.creatorAzevedo, Paula Schmidt-
Autor(es): dc.creatorBanerjee, Jay-
Autor(es): dc.creatorPhillips, Bethan E.-
Autor(es): dc.creatorAtherton, Philip J.-
Autor(es): dc.creatorPolegato, Bertha Furlan-
Autor(es): dc.creatorOkoshi, Katashi-
Autor(es): dc.creatorZanati, Silmeia Garcia-
Autor(es): dc.creatorPaiva, Sergio Alberto Rupp-
Autor(es): dc.creatorZornoff, Leonardo Antonio Mamede-
Autor(es): dc.creatorMinicucci, Marcos Ferreira-
Data de aceite: dc.date.accessioned2025-08-21T15:09:23Z-
Data de disponibilização: dc.date.available2025-08-21T15:09:23Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.exger.2021.111658-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230064-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230064-
Descrição: dc.descriptionThe objective of this study was to evaluate the association between frailty, evaluated by the Clinical Frailty Scale (CFS) and FRAIL scale, and C-terminal agrin fragment (CAF) levels with 3-month mortality following ST-segment elevation myocardial infarction (STEMI). This was a prospective observational study that included patients over the age of 18 years with STEMI admitted to the coronary intensive care unit. Within 48 h of admission, the CFS and FRAIL scale were applied and blood samples collected for serum CAF evaluation. Patients were followed for 3 months after hospital discharge, and mortality was recorded. One hundred and eleven patients were included; mean age was 62.3 ± 12.4 years, 61.3% were male and 11.7% died during the 3 months of follow-up. According to the CFS, 79.3% of the patients were classified as not frail, 12.6% as pre-frail and 8.1% as frail. According to the FRAIL scale, 31.5% of the patients were classified as not frail, 53.2% as pre-frail and 15.3% as frail. In univariate analysis, the CFS but not FRAIL scale was associated with mortality. In multiple logistic regression analysis, pre-frail/frail according to CFS (odds ratio [OR]: 6.118; CI 95%: 1.344–27.848; p = 0.019) and CAF levels (OR: 0.943; CI 95%: 0.896–0.992; p = 0.024) were associated with increased 3-month mortality. In a sub-analysis of 53 patients ≥65 years, CFS and CAF levels were associated with 3-month mortality. In conclusion, CAF levels and frailty determined by the CFS were associated with 3-month mortality after STEMI in the general and older population.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionUniversidade Estadual Paulista-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionInternal Medicine Department Botucatu Medical School Univ Estadual Paulista UNESP-
Descrição: dc.descriptionUniversity Hospital Botucatu Medical School Sao Paulo State University UNESP-
Descrição: dc.descriptionDepartment of Anesthesiology Complexo Hospitalar Santa Genoveva de Uberlândia-
Descrição: dc.descriptionFaculty of Nutrition UFG- Univ Federal de Goiás-
Descrição: dc.descriptionGeriatric Emergency Medicine University Hospitals of Leicester School of Health Science University of Leicester-
Descrição: dc.descriptionMedical Research Council-Versus Arthritis Centre for Musculoskeletal Ageing Research and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre University of Nottingham-
Descrição: dc.descriptionInternal Medicine Department Botucatu Medical School Univ Estadual Paulista UNESP-
Descrição: dc.descriptionUniversity Hospital Botucatu Medical School Sao Paulo State University UNESP-
Descrição: dc.descriptionCNPq: 304298/2019-0-
Idioma: dc.languageen-
Relação: dc.relationExperimental Gerontology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAcute myocardial infarction-
Palavras-chave: dc.subjectC-terminal agrin fragment-
Palavras-chave: dc.subjectClinical frailty scale-
Palavras-chave: dc.subjectFRAIL scale-
Título: dc.titleAssociation between frailty and C-terminal agrin fragment with 3-month mortality following ST-elevation myocardial infarction-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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