Effects of Plasma-Lyte® and 0.9% saline in renal function after deceased-donor kidney transplant: a randomized controlled trial

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatordo Nascimento Junior, Paulo-
Autor(es): dc.creatorDohler, Lucas Esteves-
Autor(es): dc.creatorOgawa, Cindy Midori Uchida-
Autor(es): dc.creatorde Andrade, Luís Gustavo Modelli-
Autor(es): dc.creatorBraz, Leandro Gobbo-
Autor(es): dc.creatorMódolo, Norma Sueli Pinheiro-
Data de aceite: dc.date.accessioned2025-08-21T17:03:12Z-
Data de disponibilização: dc.date.available2025-08-21T17:03:12Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.bjane.2021.08.015-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230041-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230041-
Descrição: dc.descriptionBackground: The influence of different crystalloid solutions infused during deceased-donor kidney transplant on the incidence of delayed graft function remains unclear. We investigated the influence of Plasma-Lyte® vs. 0.9% saline on the incidence of delayed graft function in deceased-donor kidney transplant recipients. Methods: We conducted a single-blind randomized controlled trial of 104 patients aged 18 to 65 years who underwent deceased-donor kidney transplant under general anesthesia. Patients were randomly assigned to receive either Plasma-Lyte® (n = 52) or 0.9% saline (n = 52), at the same infusion volume, for intraoperative fluid replacement. The primary outcome was the occurrence of delayed graft function. Secondary outcomes included metabolic and electrolytic changes at the end of surgery. Results: Two patients in the Plasma-Lyte® group and one in the 0.9% saline group died postoperatively and were not included for analysis. The incidence of delayed graft function in Plasma-Lyte® and 0.9% saline groups were 60.0% (95% Confidence Interval [95% CI 46.2–72.4]) and 74.5% (95% CI 61.1–84.4), respectively (p = 0.140). Mean (standard deviation) values of immediate postoperative pH and serum chloride levels in Plasma-Lyte® and 0.9% saline groups were 7.306 (0.071) and 7.273 (0.061) (p = 0.013), and 99.6 (4.2) mEq.L-1 and 103.3 (5.6) mEq.L-1, respectively (p < 0.001). All other postoperative metabolic and electrolyte variables were not statistically different at the immediate postoperative period (p > 0.05). Conclusion: In deceased-donor kidney transplant recipients, the incidence of delayed graft function is not influenced by Plasma-Lyte® or 0.9% saline used for intraoperative fluid replacement.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Faculdade de Medicina de Botucatu Departamento de Especialidades Cirúrgicas e Anestesiologia-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Faculdade de Medicina de Botucatu Hospital das Clínicas Programa de Transplante Renal-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Faculdade de Medicina de Botucatu Departamento de Especialidades Cirúrgicas e Anestesiologia-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Faculdade de Medicina de Botucatu Hospital das Clínicas Programa de Transplante Renal-
Descrição: dc.descriptionCNPq: #305109/2017-0.-
Idioma: dc.languageen-
Relação: dc.relationBrazilian Journal of Anesthesiology (English Edition)-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAcid-base equilibrium-
Palavras-chave: dc.subjectAnesthesia-
Palavras-chave: dc.subjectCrystalloid solutions-
Palavras-chave: dc.subjectDelayed graft function-
Palavras-chave: dc.subjectElectrolytes-
Palavras-chave: dc.subjectKidney transplantation-
Título: dc.titleEffects of Plasma-Lyte® and 0.9% saline in renal function after deceased-donor kidney transplant: a randomized controlled trial-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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