Exposure to maternal hyperglycemia and high-fat diet consumption after weaning in rats: repercussions on periovarian adipose tissue

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Mato Grosso (UFMT-
Autor(es): dc.creatorSaullo, Carolina M.-
Autor(es): dc.creatorSinzato, Yuri K.-
Autor(es): dc.creatorPaula, Verônyca G.-
Autor(es): dc.creatorGallego, Franciane Q.-
Autor(es): dc.creatorCorrente, José E.-
Autor(es): dc.creatorIessi, Isabela L.-
Autor(es): dc.creatorVolpato, Gustavo T.-
Autor(es): dc.creatorDamasceno, Débora C.-
Data de aceite: dc.date.accessioned2025-08-21T17:19:04Z-
Data de disponibilização: dc.date.available2025-08-21T17:19:04Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1017/S2040174421000672-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230040-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230040-
Descrição: dc.descriptionClinical and epidemiological studies show that maternal hyperglycemia can change the programming of offspring leading to transgenerational effects. These changes may be related to environmental factors, such as high-fat diet (HFD) consumption, and contribute to the comorbidity onset at the adulthood of the offspring. The objective of this study was to evaluate the hyperglycemic intrauterine environment, associated or not with an HFD administered from weaning to adult life on the periovarian adipose tissue of rat offspring Maternal diabetes was chemically induced by Streptozotocin. Female offsprings were randomly distributed into four experimental groups (n = 5 animals/group): Female offspring from control or diabetic mothers and fed an HFD or standard diet. HFD was prepared with lard enrichment and given from weaning to adulthood. On day 120 of life, the rats were anesthetized and sacrificed to obtain adipose tissue samples. Then, the hyperglycemic intrauterine environment and HFD fed after weaning caused a higher body weight, total fat, and periovarian fat in adult offspring, which could compromise the future reproductive function of these females. These rats showed higher adiposity index and adipocyte area, contributing to hypertrophied adipose tissue. Therefore, maternal diabetes itself causes intergenerational changes and, in association with the HFD consumption after weaning, exacerbated the changes in the adipose tissue of adult female offspring.-
Descrição: dc.descriptionLaboratory of Experimental Research on Gynecology and Obstetrics Postgraduate Course on Tocogynecology Botucatu Medical School Sao Paulo State University (Unesp-
Descrição: dc.descriptionResearch Support Office Botucatu Medical School Sao Paulo State University (Unesp-
Descrição: dc.descriptionLaboratory of System Physiology and Reproductive Toxicology Institute of Biological and Health Sciences Federal University of Mato Grosso (UFMT-
Descrição: dc.descriptionLaboratory of Experimental Research on Gynecology and Obstetrics Postgraduate Course on Tocogynecology Botucatu Medical School Sao Paulo State University (Unesp-
Descrição: dc.descriptionResearch Support Office Botucatu Medical School Sao Paulo State University (Unesp-
Idioma: dc.languageen-
Relação: dc.relationJournal of Developmental Origins of Health and Disease-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectadipose tissue-
Palavras-chave: dc.subjectDiabetes-
Palavras-chave: dc.subjecthigh-fat diet-
Palavras-chave: dc.subjectKeywords:-
Palavras-chave: dc.subjectobesity-
Palavras-chave: dc.subjectoffspring-
Título: dc.titleExposure to maternal hyperglycemia and high-fat diet consumption after weaning in rats: repercussions on periovarian adipose tissue-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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