Glomerulotubular pathology in dogs with subclinical ehrlichiosis

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Autor(es): dc.contributorUniversidade Federal de Uberlãndia (UFU)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal Do Maranhão (UFMA)-
Autor(es): dc.contributorThe Ohio State University-
Autor(es): dc.contributorUniversity of Florida-
Autor(es): dc.creatorCrivellenti, Leandro Zuccolotto-
Autor(es): dc.creatorCintra, Cristiane Alves-
Autor(es): dc.creatorMaia, Suellen Rodrigues-
Autor(es): dc.creatorSilva, Gyl Eanes Barros-
Autor(es): dc.creatorBorin-Crivellenti, Sofia-
Autor(es): dc.creatorCianciolo, Rachel-
Autor(es): dc.creatorAdin, Christopher A.-
Autor(es): dc.creatorTinucci-Costa, Mirela-
Autor(es): dc.creatorPennacchi, Caio Santos-
Autor(es): dc.creatorSantana, Aureo Evangelista-
Data de aceite: dc.date.accessioned2025-08-21T18:05:27Z-
Data de disponibilização: dc.date.available2025-08-21T18:05:27Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0260702-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230026-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230026-
Descrição: dc.descriptionSubclinical stage of ehrlichiosis is characterized by absence of clinical or laboratory alterations; however, it could lead to silent glomerular/tubular changes and contribute significantly to renal failure in humans and animals. The aim of this study was to evaluate glomerular and tubular alterations in dogs with subclinical ehrlichiosis. We evaluated renal biopsies of 14 bitches with subclinical ehrlichiosis and 11 control dogs. Samples were obtained from the left kidney, and the tissue obtained was divided for light microscopy, immunofluorescence, and transmission electron microscopy. Abnormalities were identified by light microscopy in 92.9% of dogs with ehrlichiosis, but not in any of the dogs of the control group. Mesangial cell proliferation and synechiae (46.1%) were the most common findings, but focal segmental glomerulosclerosis and ischemic glomeruli (38.4%), focal glomerular mesangial matrix expansion (30.7%), mild to moderate interstitial fibrosis and tubular atrophy (23%), and glomerular basement membrane spikes (23%) were also frequent in dogs with ehrlichiosis. All animals with ehrlichiosis exhibited positive immunofluorescence staining for immunoglobulins. Transmission electron microscopy from dogs with ehrlichiosis revealed slight changes such as sparse surface projections and basement membrane double contour. The subclinical phase of ehrlichiosis poses a higher risk of development of kidney damage due to the deposition of immune complexes.-
Descrição: dc.descriptionGraduate Program in Veterinary Science (PPGCV) College of Veterinary Medicine (FAMEV) Universidade Federal de Uberlãndia (UFU), Uberlãndia-
Descrição: dc.descriptionDepartment of Veterinary Clinic and Surgery Faculdade de Ciências Agrária e Veterinária (FCAV) Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)-
Descrição: dc.descriptionDepartment of Veterinary Clinics Faculdade de Medicina Veterinária e Zootecnia (FMVZ) Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)-
Descrição: dc.descriptionDepartment of Pathology Universidade Federal Do Maranhão (UFMA)-
Descrição: dc.descriptionDepartment of Veterinary Biosciences College of Veterinary Medicine The Ohio State University-
Descrição: dc.descriptionDepartment of Small Animal Clinical Sciences University of Florida-
Descrição: dc.descriptionDepartment of Veterinary Clinic and Surgery Faculdade de Ciências Agrária e Veterinária (FCAV) Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)-
Descrição: dc.descriptionDepartment of Veterinary Clinics Faculdade de Medicina Veterinária e Zootecnia (FMVZ) Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationPLoS ONE-
???dc.source???: dc.sourceScopus-
Título: dc.titleGlomerulotubular pathology in dogs with subclinical ehrlichiosis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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