Lymphatic invasion is a significant indicator of poor patient outcome in canine bladder urothelial carcinoma

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorIstituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia-Romagna (IZSLER)-
Autor(es): dc.contributorUniversity of Milan-
Autor(es): dc.contributorVetPat Laboratory-
Autor(es): dc.contributorPaulista University—UNIP-
Autor(es): dc.creatorGovoni, Verônica M.-
Autor(es): dc.creatorPigoli, Claudio-
Autor(es): dc.creatorSueiro, Felipe Augusto R.-
Autor(es): dc.creatorZuliani, Fernanda-
Autor(es): dc.creatorda Silva, Thayná O.-
Autor(es): dc.creatorQuitzan, Juliany G.-
Autor(es): dc.creatorLaufer-Amorim, Renee-
Autor(es): dc.creatorGrieco, Valeria-
Autor(es): dc.creatorFonseca-Alves, Carlos Eduardo-
Data de aceite: dc.date.accessioned2025-08-21T21:50:06Z-
Data de disponibilização: dc.date.available2025-08-21T21:50:06Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.5455/OVJ.2021.v11.i4.3-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230020-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230020-
Descrição: dc.descriptionBackground: Urothelial carcinoma (UC), also known as transitional cell carcinoma, is the most common malignant tumor of the canine urinary bladder and represents a model for studying human bladder cancer. However, the existing literature has limited data on the clinicopathological characteristics of these tumors and their prognostic value. Aim: The aim of this study was to evaluate such factors, correlating them with follow-up, in a group of 32 dogs with bladder UC. Methods: Clinical data of these cases, submitted to São Paulo State University and VetPat Private Laboratory (São Paulo/Brazil), were recorded between January 2000 and November 2019. For each case, formalin-fixed and paraffinembedded sections were stained with hematoxylin and eosin and histologically evaluated. Survival analysis was carried out, and the prognostic value of the presence of lymphatic invasion and the treatment used was determined. Results: Dogs with neoplastic lymphatic vessel invasion had a lower overall survival compared to those without lymphatic invasion, and dogs that received vinblastine in addition to surgery had higher global survival when compared to animals that received carboplatin in addition to surgery. Conclusion: The results obtained show the importance of further studies regarding the prognostic value of the two factors demonstrated as potential survival predictors, especially the lymphatic vessel invasion.-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science Sao Paulo State University—UNESP-
Descrição: dc.descriptionLaboratorio di Istologia Sede Territoriale di Milano Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia-Romagna (IZSLER)-
Descrição: dc.descriptionDepartment of Veterinary Medicine University of Milan-
Descrição: dc.descriptionVetPat Laboratory-
Descrição: dc.descriptionDepartment of Veterinary Clinic School of Veterinary Medicine and Animal Science Sao Paulo State University— UNESP-
Descrição: dc.descriptionInstitute of Health Sciences Paulista University—UNIP-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science Sao Paulo State University—UNESP-
Descrição: dc.descriptionDepartment of Veterinary Clinic School of Veterinary Medicine and Animal Science Sao Paulo State University— UNESP-
Formato: dc.format535-543-
Idioma: dc.languageen-
Relação: dc.relationOpen Veterinary Journal-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBladder cancer-
Palavras-chave: dc.subjectDog-
Palavras-chave: dc.subjectPrognosis-
Palavras-chave: dc.subjectTransitional cell carcinoma-
Título: dc.titleLymphatic invasion is a significant indicator of poor patient outcome in canine bladder urothelial carcinoma-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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