Cervicovaginal levels of human beta defensins during bacterial vaginosis

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal da Fronteira Sul (UFFS)-
Autor(es): dc.contributorUniversidade Federal do Paraná (UFPR)-
Autor(es): dc.creatorNoda-Nicolau, Nathalia Mayumi-
Autor(es): dc.creatorde Castro Silva, Mariana-
Autor(es): dc.creatorBento, Giovana Fernanda Cosi-
Autor(es): dc.creatorFerreira, Jeniffer Sena Baptista-
Autor(es): dc.creatorNovak, Juliano-
Autor(es): dc.creatorMorales, Júlia Andrade Pessoa-
Autor(es): dc.creatorTronco, Júlia Abbade-
Autor(es): dc.creatorBolpetti, Aline Nascimento-
Autor(es): dc.creatorPinto, Gabriel Vitor Silva-
Autor(es): dc.creatorPolettini, Jossimara-
Autor(es): dc.creatorMarconi, Camila-
Autor(es): dc.creatorda Silva, Márcia Guimarães-
Data de aceite: dc.date.accessioned2025-08-21T19:58:00Z-
Data de disponibilização: dc.date.available2025-08-21T19:58:00Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0260753-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/230013-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/230013-
Descrição: dc.descriptionAims To compare the cervicovaginal levels of human beta defensin (hBD)-1, 2 and 3 of women according to the status of Nugent-defined bacterial vaginosis (BV). Methods A total of 634 women of reproductive age were included in the study. Participants were equally distributed in two groups: according to the classification of vaginal smears according to Nugent criteria in normal (scores 0 to 3) and BV (scores ≥7). Cervicovaginal fluid samples were used for measurements of hBDs1, 2 and 3 levels by enzyme-linked immunosorbent assay (ELISA). Levels of each hBD were compared between the two study groups using Mann-Whitney test, with p-value <0.05 considered as significant. Odds ratio (OR) and 95% confidence interval (95% CI) were calculated for sociodemographic variables and hBD1-3 levels associated with BV a multivariable analysis. Correlation between Nugent score and measured levels of hBDs1-3 were calculated using Spearman’s test. Results Cervicovaginal fluids from women with BV showed lower levels of hBD-1 [median 2,400.00 pg/mL (0–27,800.00); p<0.0001], hBD-2 [5,600.00 pg/mL (0–45,800.00); p<0.0001] and hBD-3 [1,600.00 pg/mL (0–81,700.00); p = 0.012] when compared to optimal microbiota [hBD-1: [median 3,400.00 pg/mL (0–35,600.00), hBD-2: 12,300.00 pg/mL (0–95,300.00) and hBD-3: 3,000.00 pg/mL (0–64,300.00), respectively]. Multivariable analysis showed that lower levels of hBD-1 (OR: 2.05; 95% CI: 1.46–2.87), hBD-2 (OR: 1.85; 95% CI: 1.32–2.60) and hBD-3 (OR: 1.90; 95% CI: 1.37–2.64) were independently associated BV. Significant negative correlations were observed between Nugent scores and cervicovaginal levels of hBD-1 (Spearman’s rho = -0.2118; p = 0.0001) and hBD-2 (*Spearman’s rho = -0.2117; p = 0.0001). Conclusions Bacterial vaginosis is associated with lower cervicovaginal levels of hBDs1-3 in reproductive-aged women.-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionGraduate Program in Biomedical Sciences Medical School Universidade Federal da Fronteira Sul (UFFS), RS-
Descrição: dc.descriptionDepartment of Basic Pathology Setor de Ciências Biológicas Universidade Federal do Paraná (UFPR)-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationPLoS ONE-
???dc.source???: dc.sourceScopus-
Título: dc.titleCervicovaginal levels of human beta defensins during bacterial vaginosis-
Tipo de arquivo: dc.typelivro digital-
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