Silver nanoparticles effect on drug release of metronidazole in natural rubber latex dressing

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorAveiro of University-
Autor(es): dc.contributorTerasaki Institute for Biomedical Innovation (TIBI)-
Autor(es): dc.contributorUniversity of Caxias Do Sul (UCS)-
Autor(es): dc.creatorMiranda, Matheus Carlos Romeiro-
Autor(es): dc.creatorSato, Nicola Carlucci-
Autor(es): dc.creatorBrasil, Giovana Sant’Ana Pegorin-
Autor(es): dc.creatorPiazza, Rodolfo Debone-
Autor(es): dc.creatorJafelicci, Miguel-
Autor(es): dc.creatorde Barros, Natan Roberto-
Autor(es): dc.creatorBorges, Felipe Azevedo-
Autor(es): dc.creatorBatagin-Neto, Augusto-
Autor(es): dc.creatorde Melo Silva, William-
Autor(es): dc.creatorHerculano, Rondinelli Donizetti-
Autor(es): dc.creatorGuerra, Nayrim Brizuela-
Data de aceite: dc.date.accessioned2025-08-21T15:56:51Z-
Data de disponibilização: dc.date.available2025-08-21T15:56:51Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00289-021-03983-5-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229992-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229992-
Descrição: dc.descriptionNatural rubber latex (NRL) from Hevea brasiliensis has shown great potential for dermal applications due to its angiogenesis capacity and biocompatibility. Metronidazole (MET) is a synthetic antibiotic used to treat various infections. However, this drug reports dangerous effects when high concentrations are administered. In this study, we used silver nanoparticles (AgNPs) in order to minimize these toxicological effects. For this, the membranes were characterized by physicochemical, molecular modeling, in vitro release and hemocompatibility assays. In the release assays, 14.25% of the MET and 27.28% of the AgNP + MET complex were released simultaneously, indicating that these nanoparticles work as drug carriers. Molecular modeling simulation helped to explain the in vitro release results, showing that AgNPs can interact more efficiently with MET molecules. Moreover, similarities in reactivity between NRL and MET suggested that some drug molecules may remain in the matrix during the release process. The membranes did not present significant hemolytic activity after 24 h of incubation. These results demonstrated that the NRL + AgNP + MET membrane can be used as a dressing in the treatment of infectious processes.-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionCentre for Environmental and Marine Studies (CESAM) Aveiro of University-
Descrição: dc.descriptionSchool of Sciences Humanities and Languages São Paulo State University (UNESP)-
Descrição: dc.descriptionTerasaki Institute for Biomedical Innovation (TIBI)-
Descrição: dc.descriptionSão Paulo State University (UNESP), Campus of Itapeva-
Descrição: dc.descriptionInstitute of Biotechnology São Paulo State University (UNESP)-
Descrição: dc.descriptionArea of Exact Sciences and Engineering University of Caxias Do Sul (UCS)-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Sciences Humanities and Languages São Paulo State University (UNESP)-
Descrição: dc.descriptionSão Paulo State University (UNESP), Campus of Itapeva-
Descrição: dc.descriptionInstitute of Biotechnology São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationPolymer Bulletin-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiomaterials-
Palavras-chave: dc.subjectControlled release-
Palavras-chave: dc.subjectMetronidazole-
Palavras-chave: dc.subjectNatural rubber latex-
Palavras-chave: dc.subjectSilver nanoparticles-
Título: dc.titleSilver nanoparticles effect on drug release of metronidazole in natural rubber latex dressing-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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