Polymorphisms in Genes of Lipid Metabolism Are Associated with Type 2 Diabetes Mellitus and Periodontitis, as Comorbidities, and with the Subjects' Periodontal, Glycemic, and Lipid Profiles

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUnion of the Colleges of the Great Lakes (UNILAGO)-
Autor(es): dc.contributorSchool of Dentistry-
Autor(es): dc.creatorNicchio, Ingra G.-
Autor(es): dc.creatorCirelli, Thamiris-
Autor(es): dc.creatorNepomuceno, Rafael-
Autor(es): dc.creatorHidalgo, Marco A.R.-
Autor(es): dc.creatorRossa, Carlos-
Autor(es): dc.creatorCirelli, Joni A.-
Autor(es): dc.creatorOrrico, Silvana R.P.-
Autor(es): dc.creatorBarros, Silvana P.-
Autor(es): dc.creatorTheodoro, Letícia H.-
Autor(es): dc.creatorScarel-Caminaga, Raquel M.-
Data de aceite: dc.date.accessioned2025-08-21T19:01:46Z-
Data de disponibilização: dc.date.available2025-08-21T19:01:46Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1155/2021/1049307-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229965-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229965-
Descrição: dc.descriptionBackground. Type 2 diabetes mellitus (T2DM) and periodontitis (P) commonly occur as comorbidities, but the commonalities in the genetic makeup of affected individuals is largely unknown. Since dyslipidemia is a frequent condition in these individuals, we investigate the association of genomic variations in genes involved in lipid metabolism with periodontal, glycemic, lipid profiles, and the association with periodontitis and T2DM (as comorbidities). Methods. Based on clinical periodontal examination and biochemical evaluation, 893 subjects were divided into T2DM+P (T2DM subjects also affected by periodontitis, n=205), periodontitis (n=345), and healthy (n=343). Fourteen single-nucleotide polymorphisms (SNPs) were investigated: LDLR gene (rs5925 and rs688), APOB (rs676210, rs1042031, and rs693), ABCC8 (rs6544718 and 6544713), LPL (rs28524, rs3735964, and rs1370225), HNF1A (rs2650000), APOE (rs429358 and rs7412), and HNF4A (rs1800961). Multiple linear and logistic regressions (adjusted for covariates) were made for all populations and stratified by sex and smoking habits. Results. Individuals carrying APOB-rs1042031-CT (mainly women and never smokers) had a lower risk of developing periodontitis and T2DM (T2DM+P); altogether, this genotype was related with healthier glycemic, lipid, and periodontal parameters. Significant disease-phenotype associations with gene-sex interaction were also found for carriers of APOB-rs1676210-AG, HNF4A-rs1800961-CT, ABCC8-rs6544718-CT, LPL-rs13702-CC, and LPL-rs285-CT. Conclusions. Polymorphisms in lipid metabolism genes are associated with susceptibility to T2DM-periodontitis comorbidities, demonstrating gene-sex interaction. The APOB-rs1042031 was the most relevant gene marker related to glucose and lipid metabolism profiles, as well as with obesity and periodontitis.-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery São Paulo State University-UNESP School of Dentistry at Araraquara, SP-
Descrição: dc.descriptionDepartment of Morphology Genetics Orthodontics and Pediatric Dentistry São Paulo State University-UNESP School of Dentistry at Araraquara, SP-
Descrição: dc.descriptionAdvanced Research Center in Medicine Union of the Colleges of the Great Lakes (UNILAGO), SP-
Descrição: dc.descriptionDepartment of Periodontology University of North Carolina at Chapel Hill-UNC School of Dentistry-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery São Paulo State University-UNESP School of Dentistry at Araçatuba, SP-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery São Paulo State University-UNESP School of Dentistry at Araraquara, SP-
Descrição: dc.descriptionDepartment of Morphology Genetics Orthodontics and Pediatric Dentistry São Paulo State University-UNESP School of Dentistry at Araraquara, SP-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery São Paulo State University-UNESP School of Dentistry at Araçatuba, SP-
Idioma: dc.languageen-
Relação: dc.relationJournal of Diabetes Research-
???dc.source???: dc.sourceScopus-
Título: dc.titlePolymorphisms in Genes of Lipid Metabolism Are Associated with Type 2 Diabetes Mellitus and Periodontitis, as Comorbidities, and with the Subjects' Periodontal, Glycemic, and Lipid Profiles-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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