Carbohydrate tolerance in Amazon tambaqui (Colossoma macropomum) revealed by NMR-metabolomics - Are glucose and fructose different sugars for fruit-eating fish?

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorCentre for Functional Ecology-
Autor(es): dc.contributorUniversity of Coimbra-
Autor(es): dc.contributorUniversity School Vasco da Gama - EUVG-
Autor(es): dc.creatorFerrari, Jeisson Emerson Casimiro-
Autor(es): dc.creatorPalma, Mariana-
Autor(es): dc.creatorCarli, Gabriela Castellani-
Autor(es): dc.creatorSatiro, Thaise Mota-
Autor(es): dc.creatorTavares, Ludgero C.-
Autor(es): dc.creatorViegas, Ivan-
Autor(es): dc.creatorTakahashi, Leonardo Susumu-
Data de aceite: dc.date.accessioned2025-08-21T17:47:13Z-
Data de disponibilização: dc.date.available2025-08-21T17:47:13Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.cbd.2021.100928-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229956-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229956-
Descrição: dc.descriptionIn the present study, two approaches were followed to evaluate the metabolic responses of tambaqui (Colossoma macropomum), a frugivorous species, to intraperitoneal (IP) administration of glucose (GLU) and fructose (FRU) in fed (FED) and 10-day fasted (FAST) fish. Glucose and fructose tolerance tests were performed to assess the carbohydrate utilization and complementary NMR-metabolomics analyses were done to elucidate the impacts of sugar mobilization on the metabolic profile of plasma, liver and muscle. Blood was sampled from FED groups at 0, 3, 6 and 24 h; and at 0 and 24 h from FAST groups. Significant differences were observed in the hyperglycaemic peak between sugars at 3 h (GLU - 13.7 ± 2.0 mM vs. FRU - 8.7 ± 1.1 mM; saline 6.3 ± 0.6 mM) and on the return to normoglycaemia (GLU - 8.5 ± 2.2 mM vs. FRU - 5.2 ± 0.9 mM; saline 4.9 ± 0.6 mM) 6 h after IP on the FRU fish. The NMR-metabolomics approach allowed to conclude that tambaqui seems to be more responsive to the feeding regime (FED vs. FAST) than to the injected sugar (FRU vs. GLU). From the studied tissues, plasma showed no significant variations between feeding regimes at 24 h after IP, while muscle and liver revealed some variations on the final metabolome profile between FED and FAST groups. The metabolome variations between feeding regimes are indicative of changes on the amino acid utilization. Fish from FAST group seem to utilize amino acids as energy source rather than for protein synthesis and muscle growth. Variations on glucose concentration in muscle can also indicate different utilization of the sugars depending on the feeding regime.-
Descrição: dc.descriptionEuropean Regional Development Fund-
Descrição: dc.descriptionFundação para a Ciência e a Tecnologia-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionSão Paulo State University (Unesp) Aquaculture Center of Unesp (Caunesp)-
Descrição: dc.descriptionUniversity of Coimbra Centre for Functional Ecology Department of Life Sciences-
Descrição: dc.descriptionSão Paulo State University (Unesp) College of Agricultural and Technological Sciences (FCAT-Unesp)-
Descrição: dc.descriptionCenter for Neuroscience and Cell Biology University of Coimbra-
Descrição: dc.descriptionCIVG - Vasco da Gama Research Center University School Vasco da Gama - EUVG-
Descrição: dc.descriptionSão Paulo State University (Unesp) Aquaculture Center of Unesp (Caunesp)-
Descrição: dc.descriptionSão Paulo State University (Unesp) College of Agricultural and Technological Sciences (FCAT-Unesp)-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2020/08955-3-
Descrição: dc.descriptionCNPq: 312051/2018-2-
Descrição: dc.descriptionEuropean Regional Development Fund: Centro-01-0145-FEDER-000007-
Idioma: dc.languageen-
Relação: dc.relationComparative Biochemistry and Physiology - Part D: Genomics and Proteomics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectColossoma macropomum-
Palavras-chave: dc.subjectFasting-
Palavras-chave: dc.subjectGTT-
Palavras-chave: dc.subjectHyperglycaemia-
Palavras-chave: dc.subjectIntraperitoneal injection-
Palavras-chave: dc.subjectMetabolomics-
Título: dc.titleCarbohydrate tolerance in Amazon tambaqui (Colossoma macropomum) revealed by NMR-metabolomics - Are glucose and fructose different sugars for fruit-eating fish?-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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