Biological and antimicrobial properties of the association Ambroxol and a water-soluble viscous liquid as a vehicle for a tricalcium silicate-based sealer

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Ceará (UFC)-
Autor(es): dc.creatorde Azevedo Queiroz, Índia Olinta-
Autor(es): dc.creatorMachado, Thiago-
Autor(es): dc.creatorAlves, Camila Carneiro-
Autor(es): dc.creatorBrito, Victor Gustavo Balera-
Autor(es): dc.creatorde Vasconcelos, Bruno Carvalho-
Autor(es): dc.creatorGomes-Filho, João Eduardo-
Autor(es): dc.creatorErvolino, Edilson-
Autor(es): dc.creatorde Oliveira, Sandra Helena Penha-
Autor(es): dc.creatorDuarte, Marco Antonio Hungaro-
Data de aceite: dc.date.accessioned2025-08-21T18:51:41Z-
Data de disponibilização: dc.date.available2025-08-21T18:51:41Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10856-021-06604-9-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229943-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229943-
Descrição: dc.descriptionThis study aimed to investigate the antimicrobial and biological properties of Ambroxol associated with glycerin (GLI), propylene glycol (PG), and polyethylene glycol (PEG) as a possible vehicle for an experimental tricalcium silicate sealer, with the intention of developing a new biomaterial. Mouse undifferentiated dental pulp cells (OD-21) were cultured, and the effects of different association on cell proliferation and inflammatory cytokine production were investigated. Antimicrobial adhesion of Enterococcus faecalis to setting sealers at 2 h was evaluated. Polyethylene tubes containing experimental sealers and empty tubes were implanted into dorsal connective tissues of 12 male 3- to 4-months-old Wistar rats (250–280 g). After 7 and 30 days, the tubes were removed and processed for histological and immunohistochemical analyses. ANOVA followed by Bonferroni correction and ANOVA followed by Tukey test was used for parametric data and Kruskal–Wallis followed by Dunn for nonparametric (p < 0.05). Cell proliferation was dose-dependent, since all association were cytotoxic at higher concentrations; however, Ambroxol–PEG showed significantly higher cytotoxicity than other association (p < 0.05). In addition, irrespective of the association, no cytokine production was observed in vitro. Ambroxol–GLI reduced bacterial viability, whereas Ambroxol–PEG increased (p < 0.05). Histological examination showed no significant difference in the inflammatory response (p > 0.05) and mineralization ability in all association. Additionally, IL-1β and TNF-α were upregulated on Ambroxol–PEG in relation to Control at 07 days (p < 0.05). Ambroxol–GLI was the best vehicle for experimental tricalcium silicate sealer, as it promoted an increase in antimicrobial activity without altering the inflammatory response or mineralization ability. [Figure not available: see fulltext.]-
Descrição: dc.descriptionDepartment of Dentistry Endodontics and Dental Materials University of São Paulo (USP) Bauru School of Dentistry, Alameda Octávio Pinheiro Brisolla-
Descrição: dc.descriptionDepartment of Oral and Maxillofacial Surgery and Integrated Clinic School of Dentistry Araçatuba São Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Endodontics School of Dentistry Araçatuba São Paulo State University (Unesp), Rua José Bonifácio-
Descrição: dc.descriptionDepartment of Basic Science School of Dentistry Araçatuba São Paulo State University (Unesp), Rua José Bonifácio-
Descrição: dc.descriptionDepartment of Dentistry School of Dentistry of Sobral Federal University of Ceará (UFC), Rua Coronel Estanislau Frota-
Descrição: dc.descriptionDepartment of Oral and Maxillofacial Surgery and Integrated Clinic School of Dentistry Araçatuba São Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Endodontics School of Dentistry Araçatuba São Paulo State University (Unesp), Rua José Bonifácio-
Descrição: dc.descriptionDepartment of Basic Science School of Dentistry Araçatuba São Paulo State University (Unesp), Rua José Bonifácio-
Idioma: dc.languageen-
Relação: dc.relationJournal of Materials Science: Materials in Medicine-
???dc.source???: dc.sourceScopus-
Título: dc.titleBiological and antimicrobial properties of the association Ambroxol and a water-soluble viscous liquid as a vehicle for a tricalcium silicate-based sealer-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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