The use of menthol in skin wound healing—anti-inflammatory potential, antioxidant defense system stimulation and increased epithelialization

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorRozza, Ariane Leite-
Autor(es): dc.creatorBeserra, Fernando Pereira-
Autor(es): dc.creatorVieira, Ana Júlia-
Autor(es): dc.creatorde Souza, Eduardo Oliveira-
Autor(es): dc.creatorHussni, Carlos Alberto-
Autor(es): dc.creatorMartinez, Emanuel Ricardo Monteiro-
Autor(es): dc.creatorNóbrega, Rafael Henrique-
Autor(es): dc.creatorPellizzon, Cláudia Helena-
Data de aceite: dc.date.accessioned2025-08-21T21:12:57Z-
Data de disponibilização: dc.date.available2025-08-21T21:12:57Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/pharmaceutics13111902-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229930-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229930-
Descrição: dc.descriptionWound healing involves inflammatory, proliferative, and remodeling phases, in which various cells and chemical intermediates are involved. This study aimed to investigate the skin wound healing potential of menthol, as well as the mechanisms involved in its effect, after 3, 7, or 14 days of treatment, according to the phases of wound healing. Skin wound was performed in the back of Wistar rats, which were topically treated with vehicle cream; collagenase-based cream (1.2 U/g); or menthol-based cream at 0.25%, 0.5%, or 1.0% over 3, 7, or 14 days. Menthol cream at 0.5% accelerated the healing right from the inflammatory phase (3 days) by decreasing mRNA expression of inflammatory cytokines TNF-α and Il-6. At the proliferative phase (7 days), menthol 0.5% increased the activity of antioxidant enzymes SOD, GR, and GPx, as well as the level of GSH, in addition to decreasing the levels of inflammatory cytokines TNF-α, IL-6, and IL-1β and augmenting mRNA expression for Ki-67, a marker of cellular proliferation. At the remodeling phase (14 days), levels of inflammatory cytokines were decreased, and the level of Il-10 and its mRNA expression were increased in the menthol 0.5% group. Menthol presented skin wound healing activity by modulating the antioxidant system of the cells and the inflammatory response, in addition to stimulating epithelialization.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP), Dr. Antonio Celso W Zanin Street, 250-
Descrição: dc.descriptionDepartment of Surgery and Veterinary Anesthesiology School of Veterinary Medicine and Animal Science São Paulo State University (UNESP), Dr. Walter M Correa Street-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP), Dr. Antonio Celso W Zanin Street, 250-
Descrição: dc.descriptionDepartment of Surgery and Veterinary Anesthesiology School of Veterinary Medicine and Animal Science São Paulo State University (UNESP), Dr. Walter M Correa Street-
Descrição: dc.descriptionFAPESP: 2013/22202-4-
Descrição: dc.descriptionFAPESP: 2013/23340-1-
Descrição: dc.descriptionFAPESP: 2015/06636-0-
Descrição: dc.descriptionFAPESP: 2016/13307-5-
Descrição: dc.descriptionCNPq: 406854/2016-5-
Idioma: dc.languageen-
Relação: dc.relationPharmaceutics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntioxidant-
Palavras-chave: dc.subjectGene expression-
Palavras-chave: dc.subjectGSH-
Palavras-chave: dc.subjectIL-10-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectMenthol-
Palavras-chave: dc.subjectSkin wound healing-
Palavras-chave: dc.subjectTNF-α-
Título: dc.titleThe use of menthol in skin wound healing—anti-inflammatory potential, antioxidant defense system stimulation and increased epithelialization-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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