Resistance training mitigates hepato-cardiac changes and muscle mitochondrial protein reductions in rats with diet-induced obesity

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorLaurindo, Caroline Pancera-
Autor(es): dc.creatorRego Gregorio, Karen C.-
Autor(es): dc.creatorRippi Moreno, Ana Caroline-
Autor(es): dc.creatorViudes Agostinho, Julia Maia-
Autor(es): dc.creatorCampos, Evelyn Carvalho-
Autor(es): dc.creatorNai, Gisele Alborghetti-
Autor(es): dc.creatorNunes, Maria Tereza-
Autor(es): dc.creatorSeraphim, Patrícia Monteiro-
Data de aceite: dc.date.accessioned2025-08-21T17:21:35Z-
Data de disponibilização: dc.date.available2025-08-21T17:21:35Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.heliyon.2021.e08374-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229905-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229905-
Descrição: dc.descriptionAim: To investigate the effect of resistance training (RT) on hepatocardiovascular and muscle mitochondrial parameters in rats that were fed a high-calorie diet for 12 weeks. Main methods: The animals were divided into four groups: control (C), exercise (E), obese (O), and obese plus exercise (OE). Group E and OE rats performed resistance training by climbing on a vertical ladder with load attached to the end of the tail (1×/day, 3×/week, for 12 weeks). Group O and OE rats were fed a high-calorie diet containing chow and a cafeteria diet for 12 weeks. Under anesthesia, the heart and liver were removed for histopathological analysis, and the gastrocnemius muscle was removed for Western blotting. Key findings: Group O rats were heavier, with increased fat mass, elevated fasting glycemia, and total triglycerides, and exhibited a significant number of Kupffer cells and diffuse steatosis in the liver. Group O rats also showed increased thickness of the right ventricle, septum, and pulmonary artery. All of these parameters were attenuated by RT. PGC1-α protein levels were increased in both exercise groups. The protein levels of OXPHOS complexes III, IV, and V were reduced in Group O, while RT prevented this alteration. Significance: RT exerts a protective effect against hepato-cardiac alterations and prevents changes in the muscle mitochondrial protein profile induced by a high-calorie diet.-
Descrição: dc.descriptionDepartment of Physiotherapy - School of Sciences and Technology - Sao Paulo State University - UNESP Campus Presidente Prudente-
Descrição: dc.descriptionDepartment of Pathology - University of Western Sao Paulo-
Descrição: dc.descriptionDepartment of Physiology and Biophysics – Institute of Biomedical Sciences I University of Sao Paulo-
Descrição: dc.descriptionDepartment of Physiotherapy - School of Sciences and Technology - Sao Paulo State University - UNESP Campus Presidente Prudente-
Idioma: dc.languageen-
Relação: dc.relationHeliyon-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectHepato-cardiac alterations-
Palavras-chave: dc.subjectMitochondrial biogenesis-
Palavras-chave: dc.subjectObesity-
Palavras-chave: dc.subjectResistance training-
Título: dc.titleResistance training mitigates hepato-cardiac changes and muscle mitochondrial protein reductions in rats with diet-induced obesity-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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