Catecholamines Mediate Psychologic Stress-Induced Cancer Progression

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorBernabé, Daniel G.-
Data de aceite: dc.date.accessioned2025-08-21T23:00:22Z-
Data de disponibilização: dc.date.available2025-08-21T23:00:22Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-10-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1158/0008-5472.CAN-21-3077-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229888-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229888-
Descrição: dc.descriptionCatecholamines, which are involved in response to physical or emotional stress, have emerged as one of the main mediators of the relationship between chronic stress and cancer progression. The study in this issue of Cancer Research by Liu and colleagues reveals a new mechanism by which psychologic stress stimulates cancer progression through the D2 dopamine receptor and activation of the oxygen-independent HIF1α pathway. Although most investigations so far have focused on the action of the stress-related catecholamines norepinephrine and epinephrine on tumor cells, this study shows that dopamine and its receptor can be a potential therapeutic target. The findings broaden the understanding of the interaction of catecholamines with the tumor microenvironment and reinforces the need to look at psychologic stress as a modulator of cancer progression.See related article by Liu et al., p. 5353.-
Descrição: dc.descriptionPsychosomatic and Education Research Center Oral Oncology Center São Paulo State University (Unesp) School of Dentistry-
Descrição: dc.descriptionPsychosomatic and Education Research Center Oral Oncology Center São Paulo State University (Unesp) School of Dentistry-
Formato: dc.format5144-5146-
Idioma: dc.languageen-
Relação: dc.relationCancer research-
???dc.source???: dc.sourceScopus-
Título: dc.titleCatecholamines Mediate Psychologic Stress-Induced Cancer Progression-
Tipo de arquivo: dc.typetexto-
Aparece nas coleções:Repositório Institucional - Unesp

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