Annexin a1 mimetic peptide and piperlongumine: Anti-inflammatory profiles in endotoxin-induced uveitis

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Autor(es): dc.contributorUniversity Center Padre Albino (UNIFIPA)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUnião das Faculdades dos Grandes Lagos (Unilago)-
Autor(es): dc.creatorGirol, Ana Paula-
Autor(es): dc.creatorZanon, Caroline de Freitas-
Autor(es): dc.creatorCaruso, Ícaro Putinhon-
Autor(es): dc.creatorCosta, Sara de Souza-
Autor(es): dc.creatorSouza, Helena Ribeiro-
Autor(es): dc.creatorCornélio, Marinônio Lopes-
Autor(es): dc.creatorOliani, Sonia Maria-
Data de aceite: dc.date.accessioned2025-08-21T21:31:40Z-
Data de disponibilização: dc.date.available2025-08-21T21:31:40Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/cells10113170-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229876-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229876-
Descrição: dc.descriptionUveitis is one of the main causes of blindness worldwide, and therapeutic alternatives are worthy of study. We investigated the effects of piperlongumine (PL) and/or annexin A1 (AnxA1) mimetic peptide Ac2-26 on endotoxin-induced uveitis (EIU). Rats were inoculated with lipopolysac-charide (LPS) and intraperitoneally treated with Ac2-26 (200 µg), PL (200 and 400 µg), or Ac2-26 + PL after 15 min. Then, 24 h after LPS inoculation, leukocytes in aqueous humor, mononuclear cells, AnxA1, formyl peptide receptor (fpr)1, fpr2, and cyclooxygenase (COX)-2 were evaluated in the ocular tissues, along with inflammatory mediators in the blood and macerated supernatant. Decreased leukocyte influx, levels of inflammatory mediators, and COX-2 expression confirmed the anti-inflammatory actions of the peptide and pointed to the protective effects of PL at higher dosage. However, when PL and Ac2-26 were administered in combination, the inflammatory potential was lost. AnxA1 expression was elevated among groups treated with PL or Ac2-26 + PL but reduced after treatment with Ac2-26. Fpr2 expression was increased only in untreated EIU and Ac2-26 groups. The interaction between Ac2-26 and PL negatively affected the anti-inflammatory action of Ac2-26 or PL. We emphasize that the anti-inflammatory effects of PL can be used as a therapeutic strategy to protect against uveitis.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Physical and Morphological Sciences University Center Padre Albino (UNIFIPA)-
Descrição: dc.descriptionDepartment of Biology Institute of Biosciences Humanities and Exact Sciences (Ibilce) São Paulo State University (UNESP)-
Descrição: dc.descriptionEscola Paulista de Medicina (UNIFESP-EPM) Federal University of São Paulo-
Descrição: dc.descriptionDepartment of Phisics Institute of Biosciences Humanities and Exact Sciences (Ibilce) São Paulo State University (UNESP)-
Descrição: dc.descriptionAdvanced Research Center in Medicine (CEPAM) União das Faculdades dos Grandes Lagos (Unilago)-
Descrição: dc.descriptionDepartment of Biology Institute of Biosciences Humanities and Exact Sciences (Ibilce) São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Phisics Institute of Biosciences Humanities and Exact Sciences (Ibilce) São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2015/03359-5-
Descrição: dc.descriptionFAPESP: 2019/19949-7-
Descrição: dc.descriptionCNPq: 404190/2016-2-
Idioma: dc.languageen-
Relação: dc.relationCells-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAc2-26-
Palavras-chave: dc.subjectEye inflammation-
Palavras-chave: dc.subjectFPR receptor-
Palavras-chave: dc.subjectInflammatory mediators-
Palavras-chave: dc.subjectLipopolysaccharide-
Palavras-chave: dc.subjectNatural bioactive extracts-
Título: dc.titleAnnexin a1 mimetic peptide and piperlongumine: Anti-inflammatory profiles in endotoxin-induced uveitis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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