Prognostic value of lymphovascular and perineural invasion in squamous cell carcinoma of the tongue

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorCES University-
Autor(es): dc.contributorLas Américas-
Autor(es): dc.contributorUniversity of Antioquia-
Autor(es): dc.creatorColonia-García, Adriana-
Autor(es): dc.creatorSalazar-Peláez, Lina María-
Autor(es): dc.creatorSerna-Ortiz, Carlos Andrés-
Autor(es): dc.creatorÁlvarez-Sánchez, Luis Gonzalo-
Autor(es): dc.creatorde Andrade, Cleverton Roberto-
Data de aceite: dc.date.accessioned2025-08-21T21:49:30Z-
Data de disponibilização: dc.date.available2025-08-21T21:49:30Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.oooo.2021.08.021-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229849-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229849-
Descrição: dc.descriptionObjective: The objective of this study was to investigate the association between survival rate and lymphovascular invasion (LVI) and perineural invasion (PNI) in the tumor invasive front (TIF) of squamous cell carcinoma of the tongue (TSCC). Study Design: Seventy patients with TSCC were included. The retrospective analysis included demographic, clinical, and histopathologic data. Tissue blocks containing the TIF were stained with anti-α-smooth muscle actin and anti-S100 to detect LVI and PNI, respectively. Overall survival (OS) and disease-specific survival (DSS) were assessed using Pearson's chi-square test, Kaplan-Meier method, and Cox regression. Results: LVI and PNI were detected in 61.4% and 78.6% of the TSCC samples at the TIF, respectively. LVI and PNI were present in 54.3% of the cases and were associated with advanced clinical stage, lymph node resection, metastatic nodes, and lower survival (P < .05). The 5-year OS and DSS rates were 44% and 52%, respectively. Multivariate analysis showed that primary tumors >3.0 cm (hazard ratio = 4.29; P = .004) and a concomitant presence of LVI and PNI at the TIF (hazard ratio = 4.0; P = .012) were independent predictors for worse DSS. Conclusion: LVI and PNI, identified by immunostaining at the TIF, are potential prognostic markers of TSCC.-
Descrição: dc.descriptionSchool of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionBasic and Clinical Dentistry Group School of Dentistry CES University-
Descrição: dc.descriptionBasic Sciences Group School of Medicine CES University-
Descrição: dc.descriptionSchool of Medicine CES University-
Descrição: dc.descriptionPathology Laboratory Las Américas-
Descrição: dc.descriptionSchool of Dentistry University of Antioquia-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry São Paulo State University (UNESP). Araraquara-
Descrição: dc.descriptionSchool of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry São Paulo State University (UNESP). Araraquara-
Formato: dc.format207-215-
Idioma: dc.languageen-
Relação: dc.relationOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology-
???dc.source???: dc.sourceScopus-
Título: dc.titlePrognostic value of lymphovascular and perineural invasion in squamous cell carcinoma of the tongue-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.