Association of Proinflammatory Cytokine Levels with Stroke Severity, Infarct Size, and Muscle Strength in the Acute Phase of Stroke

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Triângulo Mineiro-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorBitencourt, Ana Carolina Silva-
Autor(es): dc.creatorTimóteo, Rodolfo Pessato-
Autor(es): dc.creatorBazan, Rodrigo-
Autor(es): dc.creatorSilva, Marcos Vinícius-
Autor(es): dc.creatorda Silveira Filho, Luiz Gonzaga-
Autor(es): dc.creatorRatkevicius, Cristhianne Molinero Andrade-
Autor(es): dc.creatorde Assunção, Thaís Soares Farnesi-
Autor(es): dc.creatorde Oliveira, Ana Paula Silva-
Autor(es): dc.creatorLuvizutto, Gustavo José-
Data de aceite: dc.date.accessioned2025-08-21T16:53:25Z-
Data de disponibilização: dc.date.available2025-08-21T16:53:25Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2021.106187-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229840-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229840-
Descrição: dc.descriptionObjective: Patterns of cytokine levels and their association with stroke severity, infarct size, and muscle strength are obscure. We aimed to analyze the immune mediators linked to T helper (Th)1, Th2, Th17, and regulatory T cell patterns and their association with stroke severity, infarct size, and muscle strength. Materials and methods: We included patients with acute stroke (n = 15) and healthy non-disabled individuals (n = 20) aged > 18 years. The dependent variables were stroke severity according to the National Institute of Health Stroke Scale (NIHSS), infarct size on computed tomography, handgrip strength by dynamometry, and global muscle strength according to the Medical Research Council (MRC) scale. The independent variables were the circulating cytokine levels. The cytokine levels were compared between the groups, and correlations between the clinical data were verified. Results: The stroke group had higher interleukin (IL)-6 (p < 0.0001) and IL-10 (p < 0.0001) levels, but lower tumor necrosis factor (TNF)-α (p = 0.036) levels than the control group. IL-10 and soluble tumor necrosis factor receptor (sTNF-RII) levels were correlated with each other (r = 0.533; p = 0.042) and infarct size (r = 0.653; p = 0.033 and r = 0.689; p = 0.018, respectively). MRC scores were positively and negatively correlated with handgrip strength of the affected side (r = 0.78; p = 0.001) and NIHSS scores (r = -0.87; p < 0.0001), respectively. Conclusions: Plasma levels of some cytokines were associated with changes in the acute phase of stroke, and IL-10 and sTNF-RII levels are potential biomarkers of infarct size.-
Descrição: dc.descriptionDepartment of Applied Physical Therapy Federal University of Triângulo Mineiro-
Descrição: dc.descriptionDepartment of Microbiology Immunology and Parasitology Federal University of Triângulo Mineiro-
Descrição: dc.descriptionDepartment of Neurology Psychology and Psychiatry Botucatu Medical School-
Descrição: dc.descriptionClinics Hospital of the Federal University of Triângulo Mineiro-
Descrição: dc.descriptionDepartment of Neurology Psychology and Psychiatry Botucatu Medical School-
Idioma: dc.languageen-
Relação: dc.relationJournal of Stroke and Cerebrovascular Diseases-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAcute stroke phase-
Palavras-chave: dc.subjectCytokines-
Palavras-chave: dc.subjectInfarct size-
Palavras-chave: dc.subjectMuscle strength-
Palavras-chave: dc.subjectStroke-
Palavras-chave: dc.subjectStroke severity-
Título: dc.titleAssociation of Proinflammatory Cytokine Levels with Stroke Severity, Infarct Size, and Muscle Strength in the Acute Phase of Stroke-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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