In vivo and in vitro models of hepatocellular carcinoma: Current strategies for translational modeling

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorVrije Universiteit Brussel-
Autor(es): dc.contributorGhent University-
Autor(es): dc.creatorRomualdo, Guilherme Ribeiro-
Autor(es): dc.creatorLeroy, Kaat-
Autor(es): dc.creatorCosta, Cícero Júlio Silva-
Autor(es): dc.creatorPrata, Gabriel Bacil-
Autor(es): dc.creatorVanderborght, Bart-
Autor(es): dc.creatorda Silva, Tereza Cristina-
Autor(es): dc.creatorBarbisan, Luís Fernando-
Autor(es): dc.creatorAndraus, Wellington-
Autor(es): dc.creatorDevisscher, Lindsey-
Autor(es): dc.creatorCâmara, Niels Olsen Saraiva-
Autor(es): dc.creatorVinken, Mathieu-
Autor(es): dc.creatorCogliati, Bruno-
Data de aceite: dc.date.accessioned2025-08-21T18:26:42Z-
Data de disponibilização: dc.date.available2025-08-21T18:26:42Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/cancers13215583-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229839-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229839-
Descrição: dc.descriptionHepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the third leading cause of cancer‐related death globally. HCC is a complex multistep disease and usually emerges in the setting of chronic liver diseases. The molecular pathogenesis of HCC varies according to the etiology, mainly caused by chronic hepatitis B and C virus infections, chronic alcohol consumption, aflatoxin‐contaminated food, and non‐alcoholic fatty liver disease associated with metabolic syndrome or diabetes mellitus. The establishment of HCC models has become essential for both basic and translational research to improve our understanding of the pathophysiology and unravel new molecular drivers of this disease. The ideal model should recapitulate key events observed during hepatocarcinogenesis and HCC progression in view of establishing effective diagnostic and therapeutic strategies to be translated into clinical practice. Despite considerable efforts currently devoted to liver cancer research, only a few anti‐HCC drugs are available, and patient prognosis and survival are still poor. The present paper provides a state-of‐the‐art overview of in vivo and in vitro models used for translational modeling of HCC with a specific focus on their key molecular hallmarks.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionFonds Wetenschappelijk Onderzoek-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Pathology School of Veterinary Medicine and Animal Science University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Biosciences Institute São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Pharmaceutical and Pharmacological Sciences Vrije Universiteit Brussel-
Descrição: dc.descriptionGut‐Liver Immunopharmacology Unit Basic and Applied Medical Sciences Liver Research Center Ghent Faculty of Medicine and Health Sciences Ghent University-
Descrição: dc.descriptionHepatology Research Unit Internal Medicine and Paediatrics Liver Research Center Ghent Faculty of Medicine and Health Sciences Ghent University-
Descrição: dc.descriptionDepartment of Gastroenterology Clinics Hospital School of Medicine University of São Paulo (HC‐FMUSP)-
Descrição: dc.descriptionDepartment of Immunology Institute of Biomedical Sciences IV University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Biosciences Institute São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 16/12015‐0-
Descrição: dc.descriptionFAPESP: 16/14420‐0-
Descrição: dc.descriptionFAPESP: 18/10953‐9-
Descrição: dc.descriptionFonds Wetenschappelijk Onderzoek: 18/10953‐9-
Descrição: dc.descriptionCNPq: 310557/2019‐4-
Descrição: dc.descriptionFonds Wetenschappelijk Onderzoek: G009514N-
Descrição: dc.descriptionFonds Wetenschappelijk Onderzoek: G010214N-
Idioma: dc.languageen-
Relação: dc.relationCancers-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAnimal model-
Palavras-chave: dc.subjectCell culture-
Palavras-chave: dc.subjectEpigenetic alteration-
Palavras-chave: dc.subjectGene mutation-
Palavras-chave: dc.subjectHepatocarcinogenesis-
Palavras-chave: dc.subjectLiver cancer-
Palavras-chave: dc.subjectTranslational research-
Título: dc.titleIn vivo and in vitro models of hepatocellular carcinoma: Current strategies for translational modeling-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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