Subacute exposure to aluminum chloride causes prolonged morphological insults in the ventral male prostate and in the female prostate of adult gerbils

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Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorda Silva Lima, Danilo-
Autor(es): dc.creatorda Silva Gomes, Liana-
Autor(es): dc.creatorde Sousa Figueredo, Esther-
Autor(es): dc.creatore Silva, Yasmin Inocêncio Fernandes-
Autor(es): dc.creatorSilva, Edvaldo Mendes-
Autor(es): dc.creatorde Souza Bovi, Thais-
Autor(es): dc.creatorTaboga, Sebastião Roberto-
Autor(es): dc.creatorMarques, Mara Rúbia-
Autor(es): dc.creatorBiancardi, Manoel Francisco-
Autor(es): dc.creatordos Santos, Fernanda Cristina Alcantara-
Data de aceite: dc.date.accessioned2025-08-21T21:38:08Z-
Data de disponibilização: dc.date.available2025-08-21T21:38:08Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/tox.23398-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229823-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229823-
Descrição: dc.descriptionAluminum (Al) is a widespread metal in the environment, and is found in fresh or processed foods, household utensils, packaging, and medicines. In addition to its high toxicity, Al can also have estrogenic agonistic effects on target organs. Considering that the Al effects on the prostate are little known, the aim of this study was to evaluate the impact of aluminum chloride (AlCl3) subacute exposure on the morphophysiology of the male ventral prostate and the female prostate of adult gerbils. Furthermore, the glandular restoration capacity in face of the Al insults was evaluated in gerbils that were submitted to 30 days of recovery. Male and female gerbils were orally exposed to AlCl3 (10 mg/kg) for 30 consecutive days. The animals were euthanized 1 day (Al1D) or 30 days (Al30D) after the end of treatment. Prostates were dissected out and processed for structural, ultrastructural and immunohistochemical analyses. Male ventral prostates and female prostates of the Al1D group showed increased cell proliferation, glandular hyperplasia, increased secretory activity and greater androgen receptor immunoreactivity. In males, Al withdrawal (Al30D) allowed a partial recovery of the prostate, as the glandular secretory activity, and frequency of androgen receptor positive cells were similar to the control group. In females, the recuperation interval (Al30D) was not enough to restore the prostatic morphology, since the gland remained hyperplastic, proliferative, and with greater androgen and estrogen receptor immunoreactivity. These data alert to the importance of avoiding Al exposure, since this metal can have a harmful and prolonged action on the prostate.-
Descrição: dc.descriptionDepartment of Histology Embryology and Cell Biology Laboratory of Microscopy Applied to Reproduction Institute of Biological Sciences Federal University of Goiás-
Descrição: dc.descriptionDepartment of Biology Laboratory of Microscopy and Microanalysis State University of São Paulo – UNESP-
Descrição: dc.descriptionDepartment of Biology Laboratory of Microscopy and Microanalysis State University of São Paulo – UNESP-
Formato: dc.format299-309-
Idioma: dc.languageen-
Relação: dc.relationEnvironmental Toxicology-
???dc.source???: dc.sourceScopus-
Título: dc.titleSubacute exposure to aluminum chloride causes prolonged morphological insults in the ventral male prostate and in the female prostate of adult gerbils-
Tipo de arquivo: dc.typelivro digital-
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