Effect of Piper cubeba total extract and isolated lignans on head and neck cancer cell lines and normal fibroblasts

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorSchool of Medicine of São José do Rio Preto (FAMERP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorNucleus of Research in Exact and Technological Sciences-
Autor(es): dc.creatorGusson-Zanetoni, Juliana Prado-
Autor(es): dc.creatorda Silva, Julliene Stephanie Guaraldi Monteiro-
Autor(es): dc.creatorPicão, Thais Bravo-
Autor(es): dc.creatorCardin, Laila Toniol-
Autor(es): dc.creatorPrates, Janesly-
Autor(es): dc.creatorSousa, Stefanie Oliveira-
Autor(es): dc.creatorHenrique, Tiago-
Autor(es): dc.creatorOliani, Sonia Maria-
Autor(es): dc.creatorTajara, Eloiza Helena-
Autor(es): dc.creatore Silva, Marcio Luis Andrade-
Autor(es): dc.creatorCunha, Nayanne Larissa-
Autor(es): dc.creatorda Silva Gomes, Ana Carolina-
Autor(es): dc.creatorLaurentiz, Rosangela Silva-
Autor(es): dc.creatorRodrigues-Lisoni, Flávia Cristina-
Data de aceite: dc.date.accessioned2025-08-21T17:23:34Z-
Data de disponibilização: dc.date.available2025-08-21T17:23:34Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jphs.2021.09.002-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229821-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229821-
Descrição: dc.descriptionThe objective of the present study was to evaluate the action of the crude hydroalcoholic extract of Piper cubeba fruits and isolated lignans (cubebin, dihydrocubebin, ethylcubebin, hinokinin and methylcubebin) on head and neck cancer cells. We evaluated the influence of the Piper cubeba extract and isolated lignans (10, 50 e 100 μg/mL) for 4, 24, 48 and 72 h, in the larynx (Hep-2) and oral (SCC-25) squamous cell carcinoma cells and normal fibroblasts, on morphology, cell proliferation and migration, cytotoxicity, genotoxicity and gene and protein expression (PTGS2, PTGER3, PTGER4, MMP2, MMP9). The results showed that the P. cubeba extract and different lignans do not alter the cellular morphology, but decrease cell proliferation and migration, have low cytotoxic and genotoxic effects, probably due to the alteration of the expression of genes and proteins involved with inflammatory process. From these data, we can conclude that the lignans cubebin and methylcubebin had a greater effect on head and neck cancer cells in the antiproliferative, antimigratory and genotoxic action, and could be the target of the development of new therapies including possible new drugs as a therapeutic resource for the treatment of head and neck cancer due to its immense range of biological properties.-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Biosciences Humanities and Exact Science (IBILCE) Campus São José do Rio Preto Department of Biology-
Descrição: dc.descriptionSchool of Medicine of São José do Rio Preto (FAMERP) Department of Molecular Biology-
Descrição: dc.descriptionDepartment of Genetics and Evolutive Biology Institute of Biosciences University of São Paulo-
Descrição: dc.descriptionUniversity of Franca (UNIFRAN) Nucleus of Research in Exact and Technological Sciences-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Engineering (FEIS) Campus Ilha Solteira Department of Physical Chemistry-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Engineering (FEIS) Campus Ilha Solteira Department of Biology and Animal Science-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Biosciences Humanities and Exact Science (IBILCE) Campus São José do Rio Preto Department of Biology-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Engineering (FEIS) Campus Ilha Solteira Department of Physical Chemistry-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Engineering (FEIS) Campus Ilha Solteira Department of Biology and Animal Science-
Formato: dc.format93-102-
Idioma: dc.languageen-
Relação: dc.relationJournal of Pharmacological Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAnti-inflammatory agents-
Palavras-chave: dc.subjectBioactive compounds-
Palavras-chave: dc.subjectPhytotherapy-
Título: dc.titleEffect of Piper cubeba total extract and isolated lignans on head and neck cancer cell lines and normal fibroblasts-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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