Usefulness of protein-based salivary markers in the diagnosis of oral potentially malignant disorders: A systematic review and meta-analysis

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Santiago de Compostela-
Autor(es): dc.contributorHealth Research Institute of Santiago de Compostela-
Autor(es): dc.contributorSão José Dos Campos-
Autor(es): dc.contributorMogi das Cruzes-
Autor(es): dc.contributorSchool of Medicine and Dentistry-
Autor(es): dc.creatorArroyo, Esteban-
Autor(es): dc.creatorDonís, Sergio Piñeiro-
Autor(es): dc.creatorPetronacci, Cintia M. Chamorro-
Autor(es): dc.creatorAlves, Monica G. Oliveira-
Autor(es): dc.creatorMendía, Xabier Marichalar-
Autor(es): dc.creatorFernandes, Darcy-
Autor(es): dc.creatorPouso, Alejandro I. Lorenzo-
Autor(es): dc.creatorBufalino, Andreia-
Autor(es): dc.creatorBravo López, Susana-
Autor(es): dc.creatorSayáns, Mario Pérez-
Data de aceite: dc.date.accessioned2025-08-21T17:56:57Z-
Data de disponibilização: dc.date.available2025-08-21T17:56:57Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3233/CBM-203043-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229812-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229812-
Descrição: dc.descriptionBy using a meta-analytical approach, this study aimed to analyse the diagnostic capacity of protein-based biomarkers in saliva for the differential diagnosis of oral potentially malignant disorders (OPMDs) and oral squamous cell carcinoma (OSCC) from healthy individuals as control group (HCG). Articles on protein-based biomarkers in saliva, which provided quantitative expression in individuals with clinical and histopathological diagnosis of OPMD or oral leukoplakia (OL) were considered eligible. Searches were conducted in eight electronic databases. The methodological quality was assessed using the Quality Assessment of Diagnostic Studies tool (QUADAS-2). Functional analysis was also performed. Meta-analyses were performed using the OpenMeta tool (Analyst). Meta-analysis was possible for 4 of the 11 biomarkers studied. Only the carcinoembryonic antigen (CEA) and the soluble fragment of cytokeratin 19 (CYFRA21) were significant for the OSCC/OPMD subgroup, both with a very low heterogeneity. CEA had an OE = 25.854 (CI95%: 13.215-38.492, p< 0.001, I2 = 0) and CYFRA21 had an OE = 9.317 (CI95%: 9.014-9.619, p< 0.001, I2 = 0). For the OPMD/HCG subgroup, only CYFRA21 was significant, with an OE = 3.679 (CI95%: 0.663-6.696, p= 0.017) although with high heterogeneity (I2 = 91.24). The CEA and CYFRA21 markers proved very useful when differentiating OSCC from OPMD. The CYFRA21 was the only protein that was capable of distinguishing between OPMD and healthy controls.-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Araraquara School of Dentistry São Paulo State University-
Descrição: dc.descriptionOral Medicine Oral Surgery and Implantology Unit Faculty of Medicine and Dentistry University of Santiago de Compostela-
Descrição: dc.descriptionORALRES Group Health Research Institute of Santiago de Compostela-
Descrição: dc.descriptionSchool of Medicine Anhembi Morumbi University São José Dos Campos-
Descrição: dc.descriptionSchool of Dentistry University of Mogi das Cruzes Mogi das Cruzes-
Descrição: dc.descriptionDepartment of Stomatology II School of Medicine and Dentistry-
Descrição: dc.descriptionProteomic Unit Health Research Institute of Santiago de Compostela-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Araraquara School of Dentistry São Paulo State University-
Formato: dc.format411-424-
Idioma: dc.languageen-
Relação: dc.relationCancer Biomarkers-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectmeta-analysis-
Palavras-chave: dc.subjectoral leukoplakia-
Palavras-chave: dc.subjectoral potentially malignant lesions-
Palavras-chave: dc.subjectprotein-based biomarkers-
Palavras-chave: dc.subjectsaliva-
Palavras-chave: dc.subjectSystematic review-
Título: dc.titleUsefulness of protein-based salivary markers in the diagnosis of oral potentially malignant disorders: A systematic review and meta-analysis-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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