Adherence to non-selective beta blockers for prevention of variceal bleeding in cirrhotic patients

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorGeneral Hospital of Northern Theater Command-
Autor(es): dc.contributorShenyang Pharmaceutical University-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorDi Cristina-Benfratelli-
Autor(es): dc.creatorAn, Yang-
Autor(es): dc.creatorXu, Xiangbo-
Autor(es): dc.creatorRen, Tianshu-
Autor(es): dc.creatorTong, Zhenhua-
Autor(es): dc.creatorRomeiro, Fernando Gomes-
Autor(es): dc.creatorMancuso, Andrea-
Autor(es): dc.creatorGuo, Xiaozhong-
Autor(es): dc.creatorQi, Xingshun-
Data de aceite: dc.date.accessioned2025-08-21T19:02:32Z-
Data de disponibilização: dc.date.available2025-08-21T19:02:32Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2147/IJGM.S326192-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229770-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229770-
Descrição: dc.descriptionBackground and Aim: Long-term use of non-selective beta blockers (NSBBs) is essential for the prevention of esophageal variceal bleeding in liver cirrhosis but may impair the patient’s adherence. The present study aimed to investigate the adherence to NSBBs to prevent variceal bleeding in cirrhotic patients. Methods: All patients who had an indication of NSBBs for the prophylaxis of variceal bleeding between February 2018 and June 2019 were screened. Clinical pharmacists gave pre-medication education and recorded the adherence to NSBBs during the patients’ hospi-talizations. Factors associated with poor adherence were evaluated by univariate logistic regression analysis. Odds ratios (OR) with 95% confidence intervals (CI) were calculated. The relationship between poor adherence during follow-up and variceal bleeding after discharge was also evaluated. Results: Overall, 108 patients were screened, of whom 12 were intolerant to NSBBs. Among the 96 remaining patients who could take NSBBs, the average change of heart rate after NSBBs was −10.49 b.p.m. Twenty-two (22.9%) patients had poor adherence to NSBBs due to their refusal to take NSBBs (n = 2), complete forgetfulness to take NSBBs (n = 10), and refusal or forgetfulness to monitor heart rate (n = 10). Univariate logistic regression analysis demonstrated that only older age was significantly associated with poor adherence (OR: 1.065, 95% CI: 1.019–1.114, P = 0.005). Patients with poor adherence during follow-up were more likely to develop variceal bleeding after discharge. Conclusion: A significant proportion of cirrhotic patients had poor adherence to NSBBs during their hospitalizations. Further studies should explore how to improve the patient’s adherence to NSBBs.-
Descrição: dc.descriptionLiver Cirrhosis Study Group Department of Gastroenterology General Hospital of Northern Theater Command-
Descrição: dc.descriptionPostgraduate College Shenyang Pharmaceutical University-
Descrição: dc.descriptionDepartment of Pharmacy General Hospital of Northern Theater Command-
Descrição: dc.descriptionSection of Medical Service General Hospital of Northern Theater Command-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu Medical School UNESP – Univ Estadual Paulista, Av. Prof. Mário Rubens Guimarães Montenegro, s/n Distrito de Rubião Jr-
Descrição: dc.descriptionMedicina Interna 1 ARNAS-Civico Di Cristina-Benfratelli-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu Medical School UNESP – Univ Estadual Paulista, Av. Prof. Mário Rubens Guimarães Montenegro, s/n Distrito de Rubião Jr-
Formato: dc.format6713-6724-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of General Medicine-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAdherence-
Palavras-chave: dc.subjectEsophageal varices-
Palavras-chave: dc.subjectLiver cirrhosis-
Palavras-chave: dc.subjectNon-selective beta blockers-
Palavras-chave: dc.subjectRisk factors-
Título: dc.titleAdherence to non-selective beta blockers for prevention of variceal bleeding in cirrhotic patients-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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