Effect of curcumin-encapsulated Pluronic® F-127 over duo-species biofilm of Streptococcus mutans and Candida albicans

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorState University of Paraíba-UEPB-
Autor(es): dc.contributorUniversity of Amsterdam and Vrije Universiteit Amsterdam-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatordos Santos, Diego Dantas Lopes-
Autor(es): dc.creatorBesegato, João Felipe-
Autor(es): dc.creatorde Melo, Priscila Borges Gobbo-
Autor(es): dc.creatorJunior, João Augusto Oshiro-
Autor(es): dc.creatorChorilli, Marlus-
Autor(es): dc.creatorDeng, Dongmei-
Autor(es): dc.creatorBagnato, Vanderlei Salvador-
Autor(es): dc.creatorde Souza Rastelli, Alessandra Nara-
Data de aceite: dc.date.accessioned2025-08-21T18:25:16Z-
Data de disponibilização: dc.date.available2025-08-21T18:25:16Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10103-021-03432-9-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229720-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229720-
Descrição: dc.descriptionTo assess the effect of curcumin-encapsulated Pluronic® F-127 (Cur-Plu) during antimicrobial photodynamic therapy (aPDT) over duo-species biofilm of Streptococcus mutans and Candida albicans. Thermal analysis, optical absorption, and fluorescence spectroscopy were evaluated. Minimum inhibitory concentration (MIC) and minimum bactericidal/fungal concentration were obtained. The biofilms were cultured for 48 h at 37 °C and treated according to the groups: P + M + L + (photosensitizer encapsulated with Pluronic® F-127 + light); P + D + L + (photosensitizer incorporated in 1% DMSO + light); P − M + L + (no Pluronic® F-127 + light); P − D + L + (1% DMSO + light); P − L + (Milli-Q water + light); P + M + L − (photosensitizer encapsulated with Pluronic® F-127 no light); P + D + L − (photosensitizer in 1% DMSO, no light); P − M + L − (Pluronic® F-127 no light); P − D + L − (1% DMSO, no light); P − L − (Milli-Q water, no light; negative control group); CHX (0.2% chlorhexidine, positive control group); and NYS (Nystatin). Dark incubation of 5 min was used. The groups that received aPDT were irradiated by blue LED (460 nm, 15 J/cm2). Cell viability of the biofilms was performed by colony-forming units (CFU/mL) and confocal microscopy. Two-way ANOVA followed by Tukey’s post hoc test was used at a significance level of 5%. P + D + L + and P + M + L + groups exhibited better log-reduction for both Candida albicans and Streptococcus mutans biofilms than P − M + L + , P − L + , and P − D + L + experimental groups. Furthermore, P + M + L + and P + D + L + showed greater reduction for Candida albicans than for Streptococcus mutans. aPDT mediated by Cur-Plu can be a potential strategy for biofilm control against duo-species biofilm of Streptococcus mutans and Candida albicans.-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry Araraquara São Paulo State University – UNESP, São Paulo-
Descrição: dc.descriptionDepartment of Restorative Dentistry School of Dentistry Araraquara São Paulo State University – UNESP, 1680 Humaitá St., MailBox: 331, São Paulo-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences Araraquara São Paulo State University – UNESP, São Paulo-
Descrição: dc.descriptionGraduate Program in Pharceutical Sciences State University of Paraíba-UEPB-
Descrição: dc.descriptionDepartment of Preventive Dentistry Academic Centre for Dentistry Amsterdam – ACTA University of Amsterdam and Vrije Universiteit Amsterdam-
Descrição: dc.descriptionDepartment of Physics and Materials Science Physics Institute of São Carlos - IFSC University of São Paulo – USP, São Paulo-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry Araraquara São Paulo State University – UNESP, São Paulo-
Descrição: dc.descriptionDepartment of Restorative Dentistry School of Dentistry Araraquara São Paulo State University – UNESP, 1680 Humaitá St., MailBox: 331, São Paulo-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences Araraquara São Paulo State University – UNESP, São Paulo-
Formato: dc.format1775-1786-
Idioma: dc.languageen-
Relação: dc.relationLasers in Medical Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiofilms-
Palavras-chave: dc.subjectCandida albicans-
Palavras-chave: dc.subjectCurcumin-
Palavras-chave: dc.subjectMicelles-
Palavras-chave: dc.subjectPhotochemotherapy-
Palavras-chave: dc.subjectStreptococcus mutans-
Título: dc.titleEffect of curcumin-encapsulated Pluronic® F-127 over duo-species biofilm of Streptococcus mutans and Candida albicans-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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