Cardiac contractility of the African sharptooth catfish, Clarias gariepinus: role of extracellular Ca2+, sarcoplasmic reticulum, and β-adrenergic stimulation

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Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMonteiro, Diana Amaral-
Autor(es): dc.creatorLopes, André Guelli-
Autor(es): dc.creatorJejcic, Nathalia Usun-
Autor(es): dc.creatorda Silva Vasconcelos, Eliton-
Autor(es): dc.creatorKalinin, Ana Lúcia-
Autor(es): dc.creatorRantin, Francisco Tadeu-
Data de aceite: dc.date.accessioned2025-08-21T15:36:38Z-
Data de disponibilização: dc.date.available2025-08-21T15:36:38Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10695-021-01023-7-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229716-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229716-
Descrição: dc.descriptionThis study investigated the dependence of contraction from extracellular Ca2+, the presence of a functional sarcoplasmic reticulum (SR), and the effects of β-adrenergic stimulation using isometric cardiac muscle preparations. Moreover, the expression of Ca2+-handling proteins such as SR-Ca2+-ATPase (SERCA), phospholamban (PLN), and Na+/Ca2+ exchanger (NCX) were also evaluated in the ventricular tissue of adult African sharptooth catfish, Clarias gariepinus, a facultative air-breathing fish. In summary, we observed that (1) contractility was strongly regulated by extracellular Ca2+; (2) inhibition of SR Ca2+-release by application of ryanodine reduced steady-state force production; (3) ventricular myocardium exhibited clear post-rest decay, even in the presence of ryanodine, indicating a decrease in SR Ca2+ content and NCX as the main pathway for Ca2+ extrusion; (4) a positive force-frequency relationship was observed above 60 bpm (1.0 Hz); (5) ventricular tissue was responsive to β-adrenergic stimulation, which caused significant increases in twitch force, kept a linear force-frequency relationship from 12 to 96 bpm (0.2 to Hz), and improved the cardiac pumping capacity (CPC); and (6) African catfish myocardium exhibited similar expression patterns of NCX, SERCA, and PLN, corroborating our findings that both mechanisms for Ca2+ transport across the SR and sarcolemma contribute to Ca2+ activator. In conclusion, this fish species displays great physiological plasticity of E-C coupling, able to improve the ability to maintain cardiac performance under physiological conditions to ecological and/or adverse environmental conditions, such as hypoxic air-breathing activity.-
Descrição: dc.descriptionDepartment of Physiological Sciences Federal University of São Carlos (UFSCar), Via Washington Luís km 235, 13565-905 São Carlos-
Descrição: dc.descriptionJoint Graduate Program in Physiological Sciences Federal University of São Carlos – UFSCar/São Paulo State University, UNESP Campus Araraquara-
Descrição: dc.descriptionJoint Graduate Program in Physiological Sciences Federal University of São Carlos – UFSCar/São Paulo State University, UNESP Campus Araraquara-
Idioma: dc.languageen-
Relação: dc.relationFish Physiology and Biochemistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCardiac function-
Palavras-chave: dc.subjectFacultative air-breathing fish-
Palavras-chave: dc.subjectForce-frequency relationship-
Palavras-chave: dc.subjectNCX-
Palavras-chave: dc.subjectPLN-
Palavras-chave: dc.subjectSERCA-
Título: dc.titleCardiac contractility of the African sharptooth catfish, Clarias gariepinus: role of extracellular Ca2+, sarcoplasmic reticulum, and β-adrenergic stimulation-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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