Protective effect of flavonoids from Passiflora edulis Sims on diabetic complications in rats

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Alfenas-
Autor(es): dc.contributorFederal University of Maranhão-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorSalles, Bruno César Correa-
Autor(es): dc.creatorLeme, Krissia Caroline-
Autor(es): dc.creatorda Silva, Marcelo Aparecido-
Autor(es): dc.creatorda Rocha, Cláudia Quintino-
Autor(es): dc.creatorTangerina, Marcelo M P-
Autor(es): dc.creatorVilegas, Wagner-
Autor(es): dc.creatorFigueiredo, Sônia A-
Autor(es): dc.creatorDuarte, Stella Maris da Silveira-
Autor(es): dc.creatorRodrigues, Maria Rita-
Autor(es): dc.creatorde Araújo Paula, Fernanda Borges-
Data de aceite: dc.date.accessioned2025-08-21T18:31:24Z-
Data de disponibilização: dc.date.available2025-08-21T18:31:24Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-09-07-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1093/jpp/rgab046-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229693-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229693-
Descrição: dc.descriptionOBJECTIVES: This study was carried out to evaluate the effects of flavonoids present in leaves of Passiflora edulis fruit on complications induced by diabetes in rats. METHODS: The extract of P. edulis leaf was obtained by 70% ethanol maceration. From the dry extract, the fractions were obtained by consecutive liquid-liquid partition with hexane, ethyl acetate and n-butanol. The content of isoorientin of ethyl acetate and n-butanol fractions was determined by ultra-performance liquid chromatography coupled with electrospray and triple quadrupole ionization (TQD) analysis in tandem mass spectrometry (UPLC-ESI-Tq-MS). Only Fr-BuOH was used to treat diabetic or not Wistar rats. Biochemical parameters, platelet aggregation and production of reactive species were evaluated. KEY FINDINGS: The UPLC-ESI-Tq-MS analysis revealed the presence of several flavonoids, among which we identified five possible flavonoids c-heterosides (luteolin-7-O-pyranosyl-3-O-glucoside, apigenin-6-8-di-C-glycoside, apigenin-6-C-arabinoside-8-C-glycoside, isoorientin, isovitexin). The diabetic rats (treated intraperitoneally with alloxan, 150 mg/kg) treated with Fr-BuOH (20 mg/kg/day for 90 days) presented improvement in blood glucose, serum levels of fructosamine, lipid profile and urea. Furthermore, the Fr-BuOH reduced both platelet aggregation and the production of oxidant species in diabetic animals. CONCLUSIONS: These results suggested that flavonoid C-glycosides present in the Fr-BuOH may be beneficial for the diabetic state, preventing complications induced by diabetes.-
Descrição: dc.descriptionDepartment of Clinical and Toxicological Analysis Faculty of Pharmaceutical Sciences Federal University of Alfenas-
Descrição: dc.descriptionDepartment of Chemistry Federal University of Maranhão-
Descrição: dc.descriptionInstitute of Biosciences Coastal Campus of São Vicente Universidade Estadual Paulista-
Descrição: dc.descriptionDepartment of Botany Institute of Biosciences University of São Paulo-
Descrição: dc.descriptionInstitute of Biosciences Coastal Campus of São Vicente Universidade Estadual Paulista-
Formato: dc.format1361-1368-
Idioma: dc.languageen-
Relação: dc.relationThe Journal of pharmacy and pharmacology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectPassiflora edulis-
Palavras-chave: dc.subjectantiplatelet-
Palavras-chave: dc.subjectdiabetes-
Palavras-chave: dc.subjectisoorientin-
Palavras-chave: dc.subjectLC-MS quantification-
Título: dc.titleProtective effect of flavonoids from Passiflora edulis Sims on diabetic complications in rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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