Are Serum Ferritin Levels a Reliable Cancer Biomarker? A Systematic Review and Meta-Analysis

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Western São Paulo (UNOESTE)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorRamírez-Carmona, Wilmer-
Autor(es): dc.creatorDíaz-Fabregat, Beatriz-
Autor(es): dc.creatorYuri Yoshigae, Andreia-
Autor(es): dc.creatorMusa de Aquino, Ariana-
Autor(es): dc.creatorScarano, Wellerson Rodrigo-
Autor(es): dc.creatorde Souza Castilho, Anthony César-
Autor(es): dc.creatorAvansini Marsicano, Juliane-
Autor(es): dc.creatorLeal do Prado, Rosana-
Autor(es): dc.creatorPessan, Juliano Pelim-
Autor(es): dc.creatorde Oliveira Mendes, Leonardo-
Data de aceite: dc.date.accessioned2025-08-21T19:50:57Z-
Data de disponibilização: dc.date.available2025-08-21T19:50:57Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/01635581.2021.1982996-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229643-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229643-
Descrição: dc.descriptionAlthough serum ferritin (SF) has been shown in several studies to be a potential cancer biomarker, the results are inconsistent. Herein, a systematic review was performed to investigate the clinical SF levels in different types of tumors in order to verify the role of SF levels as a biomarker for cancer diagnosis. The search was performed using the PubMed/Medline, Cochrane Library, and Scopus databases. Observational studies comparing SF levels between healthy adults and patients with cancer were included. The meta-analysis was carried out according to the inverse variance and random effects model. The standardized mean differences (SMDs) were assessed at 95% confidence intervals (CIs). We found that SF was higher in patients with cancer (SMD 3.07; CI 1.96,4.17), especially for head and neck cancer (SMD 3.88; CI 0.42,7.34), lung cancer (SMD 1.72; CI 0.67,2.78), pancreatic cancer (SMD 6.79; CI 5.66,7.91), and renal cell carcinoma (SMD 1.77; CI 0.48,3.05). Moreover, in the advanced stages (Stages III and IV), ferritin levels were higher than in healthy adults (SMD 4.89; CI 2.72,7.06, and SMD 8.40; CI 6.99,9.82, respectively). SF acts as a biomarker for pancreatic cancer, renal cell carcinoma, lung cancer, and head and neck cancer and is a sensitive biomarker for the detection of advanced stages of tumors.-
Descrição: dc.descriptionUniversity of Western São Paulo (UNOESTE)-
Descrição: dc.descriptionDepartment of Pediatric Dentistry and Public Heatlhy Araçatuba Dental School Univ. Estadual Paulista (UNESP)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences Univ. Estadual Paulista (UNESP)-
Descrição: dc.descriptionDepartment of Pediatric Dentistry and Public Heatlhy Araçatuba Dental School Univ. Estadual Paulista (UNESP)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences Univ. Estadual Paulista (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationNutrition and Cancer-
???dc.source???: dc.sourceScopus-
Título: dc.titleAre Serum Ferritin Levels a Reliable Cancer Biomarker? A Systematic Review and Meta-Analysis-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.