Changes in serum thiol-disulphide homeostasis in sheep with gastrointestinal nematodes

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity Center of the Federal District-UDF-
Autor(es): dc.contributorUniversity of Murcia-
Autor(es): dc.contributorAnkara City Hospital-
Autor(es): dc.creatorSchmidt, Elizabeth Moreira dos Santos-
Autor(es): dc.creatorFachiolli, Daniele Floriano-
Autor(es): dc.creatorde Oliveira, Raphaela Moreira-
Autor(es): dc.creatorAlmeida, Fabiana Alves-
Autor(es): dc.creatorPariz, Cristiano Magalhães-
Autor(es): dc.creatorde Lima Meirelles, Paulo Roberto-
Autor(es): dc.creatorCosta, Ciniro-
Autor(es): dc.creatorTvarijonaviciute, Asta-
Autor(es): dc.creatorErel, Ozcan-
Autor(es): dc.creatorNeselioglu, Salim-
Autor(es): dc.creatorCeron, Jose Joaquin-
Autor(es): dc.creatorRubio, Camila Peres-
Data de aceite: dc.date.accessioned2025-08-21T18:04:49Z-
Data de disponibilização: dc.date.available2025-08-21T18:04:49Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ani11102856-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229616-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229616-
Descrição: dc.descriptionThis work aimed to evaluate the thiol-disulphide homeostasis in serum of lambs naturally infected by gastrointestinal nematodes presenting different levels of parasite load indirectly indicated by faecal worm egg counts (EPG). Furthermore, the possible changes in the thiol-disulphide dynamic after different procedures to reduce the parasitic charge, such as the integrated crop-livestock system or anthelmintic treatment, were assessed. The results were compared with a panel of various oxidative stress and inflammatory biomarkers. The lambs were divided into three groups: animals highly infected (EPG higher than 5000) and packed cell volume (PCV) lower than 24% (G1); animals highly infected (EPG higher than 5000) and normal PCV (>24%) (G2); and animals presenting EPG lower than 5000 and normal PCV (>24%) (G3). The highly infected lambs (G1 and G2) showed lower total thiol (TT) and native thiol (SH) (p ≤ 0.01) than those from G3. After treatment, TT and SH increased significantly in all groups (p ≤ 0.01), and the disulphide (SS)/TT and SS/SH ratios decreased significantly (p < 0.01) in G1 and G2. These results show that the thiol-disulphide balance was impaired in lambs infected by gastrointestinal nematodes and that it could be potentially used as a biomarker to monitor this disease.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Veterinary Clinical Sciences School of Veterinary Medicine and Animal Science Campus of Botucatu São Paulo State University (FMVZ-UNESP)-
Descrição: dc.descriptionFaculty of Veterinary Medicine University Center of the Federal District-UDF-
Descrição: dc.descriptionDepartment of Animal Nutrition and Breeding School of Veterinary Medicine and Animal Science Campus of Botucatu São Paulo State University (FMVZ-UNESP)-
Descrição: dc.descriptionDepartment of Parasitology Biosciences Institute Campus of Botucatu São Paulo State University (FMVZ-UNESP)-
Descrição: dc.descriptionInterdisciplinary Laboratory of Clinical Analysis of the University of Murcia (Interlab-UMU) Regional Campus of International Excellence ‘Campus Mare Nostrum’ University of Murcia, Espinardo-
Descrição: dc.descriptionDepartment of Biochemistry Faculty of Medicine Ankara Yildirim Beyazit University Ankara City Hospital-
Descrição: dc.descriptionDepartment of Veterinary Clinical Sciences School of Veterinary Medicine and Animal Science Campus of Botucatu São Paulo State University (FMVZ-UNESP)-
Descrição: dc.descriptionDepartment of Animal Nutrition and Breeding School of Veterinary Medicine and Animal Science Campus of Botucatu São Paulo State University (FMVZ-UNESP)-
Descrição: dc.descriptionDepartment of Parasitology Biosciences Institute Campus of Botucatu São Paulo State University (FMVZ-UNESP)-
Descrição: dc.descriptionFAPESP: 2017/05055-
Idioma: dc.languageen-
Relação: dc.relationAnimals-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntioxidant-
Palavras-chave: dc.subjectClosantel-
Palavras-chave: dc.subjectHaemonchus-
Palavras-chave: dc.subjectIntegrated crop-livestock-
Palavras-chave: dc.subjectOxidative stress-
Palavras-chave: dc.subjectRuminants-
Título: dc.titleChanges in serum thiol-disulphide homeostasis in sheep with gastrointestinal nematodes-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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