From tissue retrieval to electron tomography: nanoscale characterization of the interface between bone and bioactive glass

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorResearch Productivity Scholarship (Process: 309408/2020-2)-
Autor(es): dc.creatorMicheletti, Chiara-
Autor(es): dc.creatorGomes-Ferreira, Pedro Henrique Silva-
Autor(es): dc.creatorCasagrande, Travis-
Autor(es): dc.creatorLisboa-Filho, Paulo Noronha-
Autor(es): dc.creatorOkamoto, Roberta-
Autor(es): dc.creatorGrandfield, Kathryn-
Data de aceite: dc.date.accessioned2025-08-21T19:02:09Z-
Data de disponibilização: dc.date.available2025-08-21T19:02:09Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1098/rsif.2021.0181-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229612-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229612-
Descrição: dc.descriptionThe success of biomaterials for bone regeneration relies on many factors, among which osseointegration plays a key role. Biogran (BG) is a bioactive glass commonly employed as a bone graft in dental procedures. Despite its use in clinical practice, the capability of BG to promote osseointegration has never been resolved at the nanoscale. In this paper, we present the workflow for characterizing the interface between newly formed bone and BG in a preclinical rat model. Areas of bone-BG contact were first identified by backscattered electron imaging in a scanning electron microscope. A focused ion beam in situ lift-out protocol was employed to prepare ultrathin samples for transmission electron microscopy analysis. The bone-BG gradual interface, i.e. the biointerphase, was visualized at the nanoscale with unprecedented resolution thanks to scanning transmission electron microscopy. Finally, we present a method to view the bone-BG interface in three dimensions using electron tomography.-
Descrição: dc.descriptionDepartment of Materials Science and Engineering, McMaster University, Hamilton, Ontario, Canada-
Descrição: dc.descriptionDepartment of Surgery and Integrated Clinic São Paulo State University Araçatuba Dental School-
Descrição: dc.descriptionCanadian Centre for Electron Microscopy, McMaster University, Hamilton, Ontario, Canada-
Descrição: dc.descriptionDepartment of Physics São Paulo State University School of Sciences-
Descrição: dc.descriptionDepartment of Basic Sciences São Paulo State University Araçatuba Dental School-
Descrição: dc.descriptionResearch Productivity Scholarship (Process: 309408/2020-2)-
Descrição: dc.descriptionSchool of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada-
Descrição: dc.descriptionDepartment of Surgery and Integrated Clinic São Paulo State University Araçatuba Dental School-
Descrição: dc.descriptionDepartment of Physics São Paulo State University School of Sciences-
Descrição: dc.descriptionDepartment of Basic Sciences São Paulo State University Araçatuba Dental School-
Formato: dc.format20210181-
Idioma: dc.languageen-
Relação: dc.relationJournal of the Royal Society, Interface-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiogran-
Palavras-chave: dc.subjectbiointerphase-
Palavras-chave: dc.subjectelectron tomography-
Palavras-chave: dc.subjectfocused ion beam-
Palavras-chave: dc.subjectosseointegration-
Palavras-chave: dc.subjectscanning transmission electron microscopy-
Título: dc.titleFrom tissue retrieval to electron tomography: nanoscale characterization of the interface between bone and bioactive glass-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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