Association Between Serum Myostatin Levels, Hospital Mortality, and Muscle Mass and Strength Following ST-Elevation Myocardial Infarction

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.creatorOliveira, Paula G.S.-
Autor(es): dc.creatorSchwed, Juliana F.-
Autor(es): dc.creatorChiuso-Minicucci, Fernanda-
Autor(es): dc.creatorDuarte, Sara R.S.-
Autor(es): dc.creatorNascimento, Lucas M.-
Autor(es): dc.creatorDorna, Mariana S.-
Autor(es): dc.creatorCosta, Nara A.-
Autor(es): dc.creatorOkoshi, Katashi-
Autor(es): dc.creatorOkoshi, Marina P.-
Autor(es): dc.creatorAzevedo, Paula S.-
Autor(es): dc.creatorPolegato, Bertha F.-
Autor(es): dc.creatorPaiva, Sergio A.R.-
Autor(es): dc.creatorZornoff, Leonardo A.M.-
Autor(es): dc.creatorMinicucci, Marcos F.-
Data de aceite: dc.date.accessioned2025-08-21T15:29:01Z-
Data de disponibilização: dc.date.available2025-08-21T15:29:01Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.hlc.2021.08.018-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229608-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229608-
Descrição: dc.descriptionAim: This study aimed to evaluate the association between serum myostatin levels, hospital mortality, and muscle mass and strength following ST-segment elevation myocardial infarction (STEMI). Methods: This was a prospective observational study. Within 48 hours of admission, bioelectrical impedance and handgrip strength were assessed and blood samples collected for myostatin evaluation. Hospital mortality was recorded. A multiple logistic regression model was also constructed, adjusted by parameters that exhibited significant differences in the univariate analysis, to evaluate the association between myostatin levels and hospital mortality. Results: One hundred and two (102) patients were included: mean age was 60.5±10.6 years, 67.6% were male, and 6.9% died during hospital stay. Univariate analysis showed that patients with lower myostatin levels had higher mortality rates. Serum myostatin levels positively correlated with handgrip strength (r=0.355; p<0.001) and appendicular skeletal muscle mass index (r=0.268; p=0.007). Receiver operating characteristic (ROC) curve analysis revealed that lower myostatin levels were associated with hospital mortality at the <2.20 ng/mL cut-off. Multiple logistic regression showed that higher serum myostatin levels were associated with reduced hospital mortality when adjusted by β blocker use (OR, 0.228; 95% CI, 0.054–0.974; p=0.046). Conclusions: Serum myostatin concentrations positively correlated with muscle mass and strength in STEMI patients. Further assessment of serum myostatin association with mortality should be conducted using a larger sample and assessing the additive value to the Global Registry of Acute Coronary Events (GRACE) or thrombolysis in myocardial infarction (TIMI) risk scores.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionUniversidade Estadual Paulista-
Descrição: dc.descriptionInternal Medicine Department Botucatu Medical School Univ Estadual Paulista UNESP-
Descrição: dc.descriptionUniversity Hospital Botucatu Medical School Sao Paulo State University UNESP-
Descrição: dc.descriptionFaculty of Nutrition Univ Federal de Goias UFG-
Descrição: dc.descriptionInternal Medicine Department Botucatu Medical School Univ Estadual Paulista UNESP-
Descrição: dc.descriptionUniversity Hospital Botucatu Medical School Sao Paulo State University UNESP-
Formato: dc.format365-371-
Idioma: dc.languageen-
Relação: dc.relationHeart Lung and Circulation-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectGrowth differentiation factor 8-
Palavras-chave: dc.subjectMuscle mass-
Palavras-chave: dc.subjectMyocardial infarction-
Palavras-chave: dc.subjectMyostatin-
Título: dc.titleAssociation Between Serum Myostatin Levels, Hospital Mortality, and Muscle Mass and Strength Following ST-Elevation Myocardial Infarction-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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