Effect of cold atmospheric plasma jet associated to polyene antifungals on candida albicans biofilms

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorLeibniz Institute for Plasma Science and Technology-
Autor(es): dc.creatorLeite, Lady Daiane Pereira-
Autor(es): dc.creatorde Oliveira, Maria Alcionéia Carvalho-
Autor(es): dc.creatorVegian, Mariana Raquel da Cruz-
Autor(es): dc.creatorSampaio, Aline da Graça-
Autor(es): dc.creatorNishime, Thalita Mayumi Castaldelli-
Autor(es): dc.creatorKostov, Konstantin Georgiev-
Autor(es): dc.creatorKoga-Ito, Cristiane Yumi-
Data de aceite: dc.date.accessioned2025-08-21T15:56:37Z-
Data de disponibilização: dc.date.available2025-08-21T15:56:37Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/molecules26195815-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229605-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229605-
Descrição: dc.descriptionThe increasing incidence of antifungal resistance represents a great challenge in the medical area and, for this reason, new therapeutic alternatives for the treatment of fungal infections are urgently required. Cold atmospheric plasma (CAP) has been proposed as a promising alternative technique for the treatment of superficial candidiasis, with inhibitory effect both in vitro and in vivo. However, little is known on the association of CAP with conventional antifungals. The aim of this study was to evaluate the effects of the association between CAP and conventional polyene antifungals on Candida albicans biofilms. C. albicans SC 5314 and a clinical isolate were used to grow 24 or 48 h biofilms, under standardized conditions. After that, the biofilms were exposed to nystatin, amphotericin B and CAP, separately or in combination. Different concentrations of the antifungals and sequences of treatment were evaluated to establish the most effective protocol. Biofilms viability after the treatments was compared to negative control. Data were compared by One-way ANOVA and post hoc Tukey (5%). The results demonstrate that 5 min exposure to CAP showed more effective antifungal effect on biofilms when compared to nystatin and amphotericin B. Additionally, it was detected that CAP showed similar (but smaller in magnitude) effects when applied in association with nystatin and amphotericin B at 40 µg/mL and 60 µg/mL. Therefore, it can be concluded that the application of CAP alone was more effective against C. albicans biofilms than in combination with conventional polyene antifungal agents.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionScience Applied to Oral Health Graduate Program of Institute of Science and Technology São Paulo State University (Unesp)-
Descrição: dc.descriptionOral Biopathology Graduate Program of Institute of Science and Technology São Paulo State University (Unesp)-
Descrição: dc.descriptionLeibniz Institute for Plasma Science and Technology-
Descrição: dc.descriptionDepartment of Physics Guaratinguetá Faculty of Engineering São Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Environment Engineering Institute of Science and Technology São Paulo State University (Unesp)-
Descrição: dc.descriptionScience Applied to Oral Health Graduate Program of Institute of Science and Technology São Paulo State University (Unesp)-
Descrição: dc.descriptionOral Biopathology Graduate Program of Institute of Science and Technology São Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Physics Guaratinguetá Faculty of Engineering São Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Environment Engineering Institute of Science and Technology São Paulo State University (Unesp)-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2019/05856-7-
Descrição: dc.descriptionCNPq: 308127/2018-80-
Idioma: dc.languageen-
Relação: dc.relationMolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntifungal-
Palavras-chave: dc.subjectCandida albicans-
Palavras-chave: dc.subjectCold plasma-
Título: dc.titleEffect of cold atmospheric plasma jet associated to polyene antifungals on candida albicans biofilms-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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