Cold atmospheric plasma jet as a possible adjuvant therapy for periodontal disease

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorLeibniz Institute for Plasma Science and Technology-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorLima, Gabriela de Morais Gouvêa-
Autor(es): dc.creatorBorges, Aline Chiodi-
Autor(es): dc.creatorNishime, Thalita Mayumi Castaldelli-
Autor(es): dc.creatorSantana-Melo, Gabriela de Fatima-
Autor(es): dc.creatorKostov, Konstantin Georgiev-
Autor(es): dc.creatorMayer, Marcia Pinto Alves-
Autor(es): dc.creatorKoga-Ito, Cristiane Yumi-
Data de aceite: dc.date.accessioned2025-08-21T21:14:48Z-
Data de disponibilização: dc.date.available2025-08-21T21:14:48Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/molecules26185590-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229546-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229546-
Descrição: dc.descriptionDue to the limitations of traditional periodontal therapies, and reported cold atmospheric plasma anti-inflammatory/antimicrobial activities, plasma could be an adjuvant therapy to periodon-titis. Porphyromonas gingivalis was grown in blood agar. Standardized suspensions were plated on blood agar and plasma-treated for planktonic growth. For biofilm, dual-species Streptococcus gordonii + P. gingivalis biofilm grew for 48 h and then was plasma-treated. XTT assay and CFU counting were performed. Cytotoxicity was accessed immediately or after 24 h. Plasma was applied for 1, 3, 5 or 7 min. In vivo: Thirty C57BI/6 mice were subject to experimental periodontitis for 11 days. Immediately after ligature removal, animals were plasma-treated for 5 min once—Group P1 (n = 10); twice (Day 11 and 13)—Group P2 (n = 10); or not treated—Group S (n = 10). Mice were euthanized on day 15. Histological and microtomography analyses were performed. Significance level was 5%. Halo diameter increased proportionally to time of exposure contrary to CFU/mL counting. Mean/SD of fibroblasts viability did not vary among the groups. Plasma was able to inhibit P. gingivalis in planktonic culture and biofilm in a cell-safe manner. Moreover, plasma treatment in vivo, for 5 min, tends to improve periodontal tissue recovery, proportionally to the number of plasma applications.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionOral Biopathology Graduate Program Institute of Science and Technology São Paulo State University (UNESP)-
Descrição: dc.descriptionLeibniz Institute for Plasma Science and Technology, Felix-Hausdorff Sts. 2-
Descrição: dc.descriptionDepartment of Physics Faculty of Engineering in Guaratinguetá São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Microbiology Institute of Biomedical Sciences Universidade de São Paulo (USP)-
Descrição: dc.descriptionDepartment of Environment Engineering São José dos Campos Institute of Science & Technology São Paulo State University (UNESP)-
Descrição: dc.descriptionOral Biopathology Graduate Program Institute of Science and Technology São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Physics Faculty of Engineering in Guaratinguetá São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Environment Engineering São José dos Campos Institute of Science & Technology São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 15/03694-3-
Descrição: dc.descriptionFAPESP: 16/07196-6-
Idioma: dc.languageen-
Relação: dc.relationMolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiocompatibility-
Palavras-chave: dc.subjectcold plasma-
Palavras-chave: dc.subjectDisinfection-
Palavras-chave: dc.subjectPeriodontitis-
Palavras-chave: dc.subjectPorphyromonas gingivalis-
Título: dc.titleCold atmospheric plasma jet as a possible adjuvant therapy for periodontal disease-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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