Mutagenicity of a novel 2-phenylbenzotriazole (non-chlorinated 2-phenylbenzotriazole-9) in mice

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorInstitute of Chemistry-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorRodrigues Tanamachi, Amanda-
Autor(es): dc.creatorFernandes, Fábio Henrique-
Autor(es): dc.creatorde Souza Vendemiatti, Josiane Aparecida-
Autor(es): dc.creatorPrediger, Patrícia-
Autor(es): dc.creatorCamparotto, Natália Gabriele-
Autor(es): dc.creatorSousa Rocha, Noeme-
Autor(es): dc.creatorAragão Umbuzeiro, Gisela-
Autor(es): dc.creatorFávero Salvadori, Daisy Maria-
Data de aceite: dc.date.accessioned2025-08-21T17:17:51Z-
Data de disponibilização: dc.date.available2025-08-21T17:17:51Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/em.22463-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229525-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229525-
Descrição: dc.descriptionDinitrophenylazo dyes can form 2-phenylbenzotriazoles (PBTAs) in the textile dyeing process upon the addition of chemical reducing agents. Some dinitrophenylazo dyes, as well as their respective reduced (non-chlorinated) and chlorinated PBTAs, are now found in rivers owing to wastewater from textile plants. This study aimed to investigate the genotoxicity of a new PBTA derived from C.I. Disperse Violet 93 azo dye, namely non-Cl PBTA-9. Primary DNA damage in the blood, liver, and colon cells, micronucleated cells in the bone marrow, and gene expression (NAT2, CYP1A1, TRP53, and CDKN1A) in liver cells were observed in mice, at acute oral exposure (gavage) doses of 5, 50, and 500 μg/kg body weight (b.w.). The non-chlorinated PBTA-9 caused DNA damage in the blood and liver (at 500 μg/kg b.w.) and in colon cells (at 5, 50, and 500 μg/kg), and increased the frequency of micronucleated cells in the bone marrow (at 5 and 50 μg/kg). No histological alterations or gene expression changes were observed. In conclusion, in vivo exposure to non-chlorinated PBTA-9 induced genetic damage in various rodent tissues, corroborating results previously obtained from the Ames test. Because this compound has been detected in rivers, exposure to humans and biota is a major concern.-
Descrição: dc.descriptionDepartment of Pathology Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionNational Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM) Institute of Chemistry-
Descrição: dc.descriptionSchool of Technology State University of Campinas (UNICAMP)-
Descrição: dc.descriptionSchool of Veterinary and Zootechnics São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Pathology Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Veterinary and Zootechnics São Paulo State University (UNESP)-
Formato: dc.format471-477-
Idioma: dc.languageen-
Relação: dc.relationEnvironmental and Molecular Mutagenesis-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject2-phenylbenzotriazole-
Palavras-chave: dc.subjectenvironmental mutagenesis-
Palavras-chave: dc.subjecttextile dye-
Palavras-chave: dc.subjectwater pollution-
Título: dc.titleMutagenicity of a novel 2-phenylbenzotriazole (non-chlorinated 2-phenylbenzotriazole-9) in mice-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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