Intrathecal Transplantation of Autologous and Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells in Dogs

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorBenavides, Felipe Pérez-
Autor(es): dc.creatorPinto, Giovana Boff Araujo-
Autor(es): dc.creatorHeckler, Marta Cristina Thomas-
Autor(es): dc.creatorHurtado, Diana Milena Rodríguez-
Autor(es): dc.creatorTeixeira, Livia Ramos-
Autor(es): dc.creatorMonobe, Marina Mitie de Souza-
Autor(es): dc.creatorMachado, Gisele Fabrino-
Autor(es): dc.creatorde Melo, Guilherme Dias-
Autor(es): dc.creatorRodríguez-Sánchez, Diego Noé-
Autor(es): dc.creatorAlvarenga, Fernanda da Cruz Landim e-
Autor(es): dc.creatorAmorim, Rogério Martins-
Data de aceite: dc.date.accessioned2025-08-21T15:44:22Z-
Data de disponibilização: dc.date.available2025-08-21T15:44:22Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1177/09636897211034464-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229488-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229488-
Descrição: dc.descriptionThe route used in the transplantation of mesenchymal stem cells (MSCs) can directly affect the treatment success. The transplantation of MSCs via the intrathecal (IT) route can be an important therapeutic strategy for neurological disorders. The objective of this study was to evaluate the safety and feasibility of the IT transplantation of autologous (Auto-MSCs) and allogeneic (Allo-MSCs) bone marrow mesenchymal stem cells (BM-MSCs) in healthy dogs. Based on neurodisability score, cerebrospinal fluid (CSF) and magnetic resonance imaging (MRI), no significant differences from the control group were observed on day 1 or day 5 after IT Auto- or Allo-MSCs transplantation (P > 0.05). In addition, analysis of matrix metalloproteinase (MMP)-2 and MMP-9 expression in the CSF revealed no significant differences (P > 0.05) at 5 days after IT transplantation in the Auto- or Allo-MSCs group when compared to the control. Intrathecal transplantation of BM-MSCs in dogs provides a safe, easy and minimally invasive route for the use of cell-based therapeutics in central nervous system diseases.-
Descrição: dc.descriptionDepartment of Veterinary Clinics School of Veterinary Medicine and Animal Science São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Animal Reproduction and Veterinary Radiology São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Anesthesiology São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Clinics Surgery and Animal Reproduction São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Veterinary Clinics School of Veterinary Medicine and Animal Science São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Animal Reproduction and Veterinary Radiology São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Anesthesiology São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Clinics Surgery and Animal Reproduction São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationCell Transplantation-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbone marrow mesenchymal stem cells-
Palavras-chave: dc.subjectcell-based therapy-
Palavras-chave: dc.subjectcerebrospinal fluid-
Palavras-chave: dc.subjectintrathecal route-
Palavras-chave: dc.subjectmatrix metalloproteinase-
Título: dc.titleIntrathecal Transplantation of Autologous and Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells in Dogs-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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