Effect of probiotic, prebiotic, and synbiotic on the gut microbiota of autistic children using an in vitro gut microbiome model

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity of California-
Autor(es): dc.contributorUniversité Clermont Auvergne-
Autor(es): dc.contributorParis University-
Autor(es): dc.contributorUniversity of Antioquia-
Autor(es): dc.creatorDuque, Ana Luiza Rocha Faria-
Autor(es): dc.creatorDemarqui, Fernanda Manaia-
Autor(es): dc.creatorSantoni, Mariana Marchi-
Autor(es): dc.creatorZanelli, Cleslei Fernando-
Autor(es): dc.creatorAdorno, Maria Angela Tallarico-
Autor(es): dc.creatorMilenkovic, Dragan-
Autor(es): dc.creatorMesa, Victoria-
Autor(es): dc.creatorSivieri, Katia-
Data de aceite: dc.date.accessioned2025-08-21T21:14:38Z-
Data de disponibilização: dc.date.available2025-08-21T21:14:38Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.foodres.2021.110657-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229445-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229445-
Descrição: dc.descriptionImbalances in gut microbiota composition occur in individuals with autism spectrum disorder (ASD). The administration of probiotics, prebiotics, and synbiotics is emerging as a potential and promising strategy for regulating the gut microbiota and improving ASD-related symptoms. We first investigated the survival of the probiotics Limosilactobacillus (L.) reuteri and Bifidobacterium (B.) longum alone, mixed and combined with a galacto-oligosaccharide (GOS) under simulated gastrointestinal conditions. Next, we evaluated the impact of probiotics (L. reuteri + B. longum), prebiotic (GOS), and synbiotic (L. reuteri + B. longum + GOS) on gut microbiota composition and metabolism of children with ASD using an in vitro fermentation model (SHIME®). The combination of L. reuteri, B. longum, and GOS showed elevated gastrointestinal resistance. The probiotic, prebiotic, and synbiotic treatments resulted in a positive modulation of the gut microbiota and metabolic activity of children with ASD. More specifically, the probiotic treatment increased the relative abundance of Lactobacillus, while the prebiotic treatment increased the relative abundance of Bifidobacterium and decreased the relative abundance of Lachnoclostridium. Changes in microbial metabolism were associated with increased short-chain fatty acid concentrations and reduced ammonium levels, particularly in the prebiotic and synbiotic treatments.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Food and Nutrition School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Biological Sciences School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Hydraulics and Sanitation School of Engineering of São Carlos University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Internal Medicine UC Davis School of Medicine University of California-
Descrição: dc.descriptionINRAE UNH Université Clermont Auvergne-
Descrição: dc.descriptionFaculty of Pharmacy Paris University-
Descrição: dc.descriptionFood and Human Nutrition Research Group University of Antioquia-
Descrição: dc.descriptionDepartment of Food and Nutrition School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Biological Sciences School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2017/01157-1-
Descrição: dc.descriptionFAPESP: 2018/26645-1-
Idioma: dc.languageen-
Relação: dc.relationFood Research International-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAutism spectrum disorder-
Palavras-chave: dc.subjectBifidobacterium longum-
Palavras-chave: dc.subjectGalacto-oligosaccharide-
Palavras-chave: dc.subjectLimosilactobacillus reuteri-
Palavras-chave: dc.subjectMicrobiota modulation-
Palavras-chave: dc.subjectSHIME®-
Título: dc.titleEffect of probiotic, prebiotic, and synbiotic on the gut microbiota of autistic children using an in vitro gut microbiome model-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.