Association Between Metabolic Syndrome and Immunohistochemical Profile at Breast Cancer Diagnosis in Postmenopausal Women

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorClaretian School of Medicine - Rio Claro University Center-
Autor(es): dc.creatorMotoki, Andre H.-
Autor(es): dc.creatorButtros, Daniel A.B.-
Autor(es): dc.creatorGaspar, Ana Luisa-
Autor(es): dc.creatorAlmeida-Filho, Benedito S.-
Autor(es): dc.creatorCarvalho-Pessoa, Eduardo-
Autor(es): dc.creatorVespoli, Heloisa D.L-
Autor(es): dc.creatorNahas-Neto, Jorge-
Autor(es): dc.creatorNahas, Eliana A.P.-
Data de aceite: dc.date.accessioned2025-08-21T17:24:22Z-
Data de disponibilização: dc.date.available2025-08-21T17:24:22Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.clbc.2021.07.009-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229429-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229429-
Descrição: dc.descriptionBackground: The aim of this study was to evaluate the association between metabolic syndrome (MetS) and the immunohistochemical profile of breast cancer (BC) in postmenopausal women. Methods: This cross-sectional cohort study included 189 women, aged 45 to 75years and amenorrhea >12 months, with newly diagnosed BC and no previous cancer treatment. Clinical, anthropometric and biochemical data were collected, as well as data on BC hormone status (estrogen receptor, ER; progesterone receptor, PR; human epidermal growth factor receptor-2, HER-2), and epithelial proliferative activity (Ki-67). Tumors were divided into 5 subtypes:luminal A, luminal B HER-2 negative, luminal B HER-2 positive, non-luminal HER-2, and triple negative. Women with three or more of the following criteria were diagnosed with MetS: waist circumference ≥88cm; triglycerides ≥150mg/dL; HDL-cholesterol <50mg/dL; blood pressure ≥130/85mmHg; glucose ≥100mg/dL. Results: Sixty-three (33.3%) of the 189 patients had MetS at the time of diagnosis. Women with MetS had a higher frequency of tumors ≤ 2cm than women without MetS (49.2% vs. 31.8%) (P = .038). There were no differences in histological grade, staging, or axillary lymph node metastasis (P > .05). The proportion of PR-positive (P = .006), HER-2-negative (P = .034), and luminal B HER-2-negative (P = .038) tumors was higher among patients with MetS compared to women without MetS (79.4% vs. 61.8%, 89.9% vs. 78.6% and 44.5% vs. 27.8%, respectively). Multivariate analysis adjusted for age, time since menopause and BMI showed a higher risk for luminal B HER-2-negative tumors among women with MetS (OR 2.00, 95% CI 1.03-3.89), obese patients (OR 2.03, 95% CI 1.06-3.90), and women with abdominal obesity (OR 1.96, 95% CI 1.01-4.03). Conclusion: In postmenopausal women with newly diagnosed BC, the presence of MetS was associated with smaller tumor size, PR-positive and HER-2-negative status, and the luminal B tumor subtype.-
Descrição: dc.descriptionGraduate Program in Tocogynecology Botucatu Medical School Sao Paulo State University - UNESP-
Descrição: dc.descriptionClaretian School of Medicine - Rio Claro University Center-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Botucatu Medical School Sao Paulo State University - UNESP-
Descrição: dc.descriptionGraduate Program in Tocogynecology Botucatu Medical School Sao Paulo State University - UNESP-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Botucatu Medical School Sao Paulo State University - UNESP-
Formato: dc.formate253-e261-
Idioma: dc.languageen-
Relação: dc.relationClinical Breast Cancer-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBreast cancer subtypes-
Palavras-chave: dc.subjectHormone receptor status-
Palavras-chave: dc.subjectMenopause-
Palavras-chave: dc.subjectMetabolic Health-
Palavras-chave: dc.subjectObesity-
Título: dc.titleAssociation Between Metabolic Syndrome and Immunohistochemical Profile at Breast Cancer Diagnosis in Postmenopausal Women-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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