Natural rubber dressing loaded with silver sulfadiazine for the treatment of burn wounds infected with Candida spp.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Caxias do Sul (UCS)-
Autor(es): dc.contributorTerasaki Institute for Biomedical Innovation (TIBI)-
Autor(es): dc.creatorTanaka, Jean Lucas-
Autor(es): dc.creatorCosta-Orlandi, Caroline Barcelos-
Autor(es): dc.creatorBurd, Betina Sayeg-
Autor(es): dc.creatorPegorin, Giovana Sant'Ana-
Autor(es): dc.creatorda Silva, Thainá Venâncio-
Autor(es): dc.creatorGuerra, Nayrim Brizuela-
Autor(es): dc.creatorMendes-Giannini, Maria José Soares-
Autor(es): dc.creatorFusco-Almeida, Ana Marisa-
Autor(es): dc.creatorHerculano, Rondinelli Donizetti-
Autor(es): dc.creatorde Barros, Natan Roberto-
Data de aceite: dc.date.accessioned2025-08-21T20:09:52Z-
Data de disponibilização: dc.date.available2025-08-21T20:09:52Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-10-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ijbiomac.2021.08.102-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229397-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229397-
Descrição: dc.descriptionMillions of people are burned worldwide every year and 265,000 of the cases are fatal. The development of burn treatment cannot consist only of the administration of a single drug. Due to the infection risk, antibiotics are used in conjunction with gels and damp bandages. In this work, an inexpensive curative based on silver sulfadiazine (SS) and natural rubber latex (NRL) was developed to treat burn wounds. It was produced by the casting method. The infrared spectrum presented no interaction between drug and biopolymer. At the same time, electronic micrographs showed that the SS crystals are inserted on the polymeric dressing surface. Mechanical properties after the drug incorporation were considered suitable for dermal application. About 32.4% of loaded SS was released in 192 h by the dressings that also inhibited the growth of Candida albicans and Candida parapsilosis at 75.0 and 37.5 μg·mL−1, respectively. The curative proved to be biocompatible when applied to fibroblast cells, in addition to enhancing cellular proliferation and, in the hemocompatibility test, no hemolytic effects were observed. The good results in mechanical, antifungal and biological assays, combined with the average bandage cost of $0.10, represent an exciting alternative for treating burn wounds.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionBioengineering & Biomaterials Group São Paulo State University (UNESP) School of Pharmaceutical Sciences, Km01 Araraquara-Jaú Road-
Descrição: dc.descriptionDepartment of Biotechnology and Bioprocesses Engineering São Paulo State University (UNESP) School of Pharmaceutical Sciences, Km01 Araraquara-Jaú Road-
Descrição: dc.descriptionDepartment of Clinical Analysis São Paulo State University (UNESP) School of Pharmaceutical Sciences, Km01 Araraquara-Jaú Road-
Descrição: dc.descriptionArea of Exact Sciences and Engineering University of Caxias do Sul (UCS), 1130 Francisco Getúlio Vargas Street, Caxias do Sul-
Descrição: dc.descriptionTerasaki Institute for Biomedical Innovation (TIBI), 1018 Westwood Blvd-
Descrição: dc.descriptionBioengineering & Biomaterials Group São Paulo State University (UNESP) School of Pharmaceutical Sciences, Km01 Araraquara-Jaú Road-
Descrição: dc.descriptionDepartment of Biotechnology and Bioprocesses Engineering São Paulo State University (UNESP) School of Pharmaceutical Sciences, Km01 Araraquara-Jaú Road-
Descrição: dc.descriptionDepartment of Clinical Analysis São Paulo State University (UNESP) School of Pharmaceutical Sciences, Km01 Araraquara-Jaú Road-
Descrição: dc.descriptionFAPESP: 2011/17411-8-
Descrição: dc.descriptionFAPESP: 2014/17526-8-
Descrição: dc.descriptionFAPESP: 2017/18388-6-
Descrição: dc.descriptionFAPESP: 2017/19603--
Formato: dc.format597-606-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Biological Macromolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntimicrobial-
Palavras-chave: dc.subjectBiomaterial-
Palavras-chave: dc.subjectBiopolymer-
Palavras-chave: dc.subjectDressing-
Palavras-chave: dc.subjectNatural rubber latex-
Palavras-chave: dc.subjectSilver sulfadiazine-
Título: dc.titleNatural rubber dressing loaded with silver sulfadiazine for the treatment of burn wounds infected with Candida spp.-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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