Congenital Anomalies Programmed by Maternal Diabetes and Obesity on Offspring of Rats

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Mato Grosso-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorAraujo-Silva, Vanessa Caruline-
Autor(es): dc.creatorSantos-Silva, Alice-
Autor(es): dc.creatorLourenço, Andressa Silva-
Autor(es): dc.creatorBarros-Barbosa, Cristielly Maria-
Autor(es): dc.creatorMoraes-Souza, Rafaianne Queiroz-
Autor(es): dc.creatorSoares, Thaigra Sousa-
Autor(es): dc.creatorKarki, Barshana-
Autor(es): dc.creatorPaula, Verônyca Gonçalves-
Autor(es): dc.creatorSinzato, Yuri Karen-
Autor(es): dc.creatorDamasceno, Débora Cristina-
Autor(es): dc.creatorVolpato, Gustavo Tadeu-
Data de aceite: dc.date.accessioned2025-08-21T19:55:54Z-
Data de disponibilização: dc.date.available2025-08-21T19:55:54Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-08-10-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fphys.2021.701767-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229394-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229394-
Descrição: dc.descriptionEmbryo-fetal exposure to maternal disorders during intrauterine life programs long-term consequences for the health and illness of offspring. In this study, we evaluated whether mild diabetic rats that were given high-fat/high-sugar (HF/HS) diet presented maternal and fetal changes at term pregnancy. Female rats received citrate buffer (non-diabetic-ND) or streptozotocin (diabetic-D) after birth. According to the oral glucose tolerance test (OGTT), the experimental groups (n = 11 animals/group) were composed of non-diabetic and diabetic receiving standard diet (S) or HF/HS diet. High-fat/high-sugar diet (30% kcal of lard) in chow and water containing 5% sucrose and given 1 month before mating and during pregnancy. During and at the end of pregnancy, obesity and diabetes features were determined. After laparotomy, blood samples, periovarian fat, and uterine content were collected. The diabetic rats presented a higher glycemia and percentage of embryonic losses when compared with the NDS group. Rats DHF/HS presented increased obesogenic index, caloric intake, and periovarian fat weight and reduced gravid uterus weight in relation to the other groups. Besides, this association might lead to the inflammatory process, confirmed by leukocytosis. Obese rats (NDHF/HS and DHF/HS) showed higher triglyceride levels and their offspring with lower fetal weight and ossification sites, indicating intrauterine growth restriction. This finding may contribute to vascular alterations related to long-term hypertensive disorders in adult offspring. The fetuses from diabetic dams showed higher percentages of skeletal abnormalities, and DHF/HS dams still had a higher rate of anomalous fetuses. Thus, maternal diabetes and/or obesity induces maternal metabolic disorders that contribute to affect fetal development and growth.-
Descrição: dc.descriptionLaboratory of System Physiology and Reproductive Toxicology Institute of Biological and Health Sciences Federal University of Mato Grosso-
Descrição: dc.descriptionLaboratory of Experimental Research on Gynecology and Obstetrics Postgraduate Program on Tocogynecology São Paulo State University-
Descrição: dc.descriptionLaboratory of Experimental Research on Gynecology and Obstetrics Postgraduate Program on Tocogynecology São Paulo State University-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbiochemical-
Palavras-chave: dc.subjecthyperglycemia-
Palavras-chave: dc.subjectmalformation-
Palavras-chave: dc.subjectobesity-
Palavras-chave: dc.subjectpregnancy-
Palavras-chave: dc.subjectrat-
Título: dc.titleCongenital Anomalies Programmed by Maternal Diabetes and Obesity on Offspring of Rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.