Probiotics for the treatment of depression and anxiety: A systematic review and meta-analysis of randomized controlled trials

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorSt. Joseph's Healthcare-
Autor(es): dc.contributorPGIMER-
Autor(es): dc.contributorUniversidade Anhembi-Morumbi-
Autor(es): dc.contributorUniversidade Mogi Das Cruzes-
Autor(es): dc.contributorHigh Institute of Public Health-Alexandria University-
Autor(es): dc.contributorTanta Chest Hospital-
Autor(es): dc.contributorUniversidade Do Vale Do Paraíba-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorEl Dib, Regina-
Autor(es): dc.creatorPeriyasamy, Aravind Gandhi-
Autor(es): dc.creatorde Barros, Jessica Lima-
Autor(es): dc.creatorFrança, Carolina Gonzales-
Autor(es): dc.creatorSenefonte, Fernanda Labiapari-
Autor(es): dc.creatorVesentini, Giovana-
Autor(es): dc.creatorAlves, Mônica Ghislaine Oliveira-
Autor(es): dc.creatorRodrigues, João Vitor da Silva-
Autor(es): dc.creatorGomaa, Huda-
Autor(es): dc.creatorGomes Júnior, José Reinaldo-
Autor(es): dc.creatorCosta, Lucas Fernandes-
Autor(es): dc.creatorVon Ancken, Thainá de Souza-
Autor(es): dc.creatorToneli, Carla-
Autor(es): dc.creatorSuzumura, Erica A.-
Autor(es): dc.creatorKawakami, Claudio Pereira-
Autor(es): dc.creatorFaustino, Eliseu Gabriel-
Autor(es): dc.creatorJorge, Eliane Chaves-
Autor(es): dc.creatorAlmeida, Janete Dias-
Autor(es): dc.creatorKapoor, Anil-
Data de aceite: dc.date.accessioned2025-08-21T22:39:12Z-
Data de disponibilização: dc.date.available2025-08-21T22:39:12Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.clnesp.2021.07.027-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229376-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229376-
Descrição: dc.descriptionBackground & aim: Probiotics in the gut have been suggested to have a beneficial effect on anxiety response and depressive disorder. Hence we conducted a systematic review and meta-analysis to summarize the effects of probiotics associated with or without pharmacological or psychological therapies in patients with depressive and/or anxiety symptoms or disorders. Methods: We conducted searches of MEDLINE, EMBASE, CENTRAL, PsycINFO, CINAHL, ProQuest, LILACS, and Web of Science up to February 2020 to identify randomized controlled trials (RCTs) investigating the efficacy of probiotics associated with or without pharmacological or psychological therapies for patient-important outcomes including relief of depressive, anxiety and stress symptoms, cognitive functions, adverse events and quality of life. We used the GRADE approach to rate the overall certainty of the evidence by outcome. The protocol of the systematic review was registered with PROPSERO and published under the number CRD4202016329. Results: 16 RCTs including 1,125 patients proved eligible. Results suggested a significant improvement in using Beck Depression Index (MD, −3.20 [95% CI, −5.91 to −0.49], p = 0.02; I2 = 21%, p = 0.28) for depression symptoms and State-Trait Anxiety Inventory (STAI) (MD, −6.88 [95% CI, −12.35 to −1.41], p = 0.01; I2 = 24%, p = 0.25) for anxiety with overall certainty in evidence rated as moderate and low, respectively. However, Depression Scale (DASS-Depression) (MD, 2.01 [95% CI, −0.80 to 4.82], p = 0.16; I2 = 0%, p = 0.62), Montgomery-Asberg Depression Rating Scale (MADRAS) (MD, −2,41 [95% CI, −10,55 to 5,72], p = 0,56; I2 = 87%, p = 0,006), Anxiety scale (DASS-Anxiety) (MD, 0.49 [95% CI, −4.05 to 5.02], p = 0.83; I2 = 74%, p = 0.05), and Stress Scale (DASS-Stress) (MD, 0.84 [95% CI, −2.64 to 4.33], p = 0.64; I2 = 34%, p = 0.22) showed no significant decrease in the relief of depression, anxiety and stress symptoms of probiotics compared to placebo with overall certainty in evidence rated as very low for all outcomes. We also found no differences in the Beck Anxiety Index (BAI) (MD, −3.21 [95% CI, −6.50 to 0.08], p = 0.06; I2 = 0%, p = 0.88) with overall certainty in evidence rated as low. Results suggested a non-statistically significantly effect of probiotics in the adverse events outcomes. Conclusions: The current review suggests that probiotics may improve symptoms of depression and anxiety in clinical patients. However, given the limitations in the included studies, RCTs with long-term follow-up and large sample sizes are needed.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology Universidade Estadual Paulista-
Descrição: dc.descriptionMcMaster Institute of Urology McMaster University St. Joseph's Healthcare-
Descrição: dc.descriptionDepartment of Community Medicine & School of Public Health PGIMER-
Descrição: dc.descriptionLaboratory of Experimental Research on Gynecology and Obstetrics Postgraduate Course on Tocogynecology Botucatu Medical School São Paulo State University (Unesp)-
Descrição: dc.descriptionUniversidade Anhembi-Morumbi Campus São José Dos Campos-
Descrição: dc.descriptionSchool of Dentistry Universidade Mogi Das Cruzes-
Descrição: dc.descriptionHigh Institute of Public Health-Alexandria University-
Descrição: dc.descriptionDrug Information Center Tanta Chest Hospital-
Descrição: dc.descriptionUniversidade Do Vale Do Paraíba-
Descrição: dc.descriptionDepartament of Preventive Medicine Faculdade de Medicina - FMUSP Universidade de Sao Paulo-
Descrição: dc.descriptionDepartment of Surgical Specialties and Anesthesiology Department Botucatu Medical School UNESP - Universidade Estadual Paulista-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology Universidade Estadual Paulista-
Descrição: dc.descriptionLaboratory of Experimental Research on Gynecology and Obstetrics Postgraduate Course on Tocogynecology Botucatu Medical School São Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Surgical Specialties and Anesthesiology Department Botucatu Medical School UNESP - Universidade Estadual Paulista-
Formato: dc.format75-90-
Idioma: dc.languageen-
Relação: dc.relationClinical Nutrition ESPEN-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAnxiety-
Palavras-chave: dc.subjectDepression-
Palavras-chave: dc.subjectProbiotics-
Palavras-chave: dc.subjectRandomized controlled trials-
Palavras-chave: dc.subjectStress-
Palavras-chave: dc.subjectSystematic review-
Título: dc.titleProbiotics for the treatment of depression and anxiety: A systematic review and meta-analysis of randomized controlled trials-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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