Cirrhosis regression after SVR with indirect methods of fibrosis analysis: How far is it real?

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorTaubaté Medical School - UNITAU-
Autor(es): dc.creatorBarbosa, Walnei Fernandes-
Autor(es): dc.creatorAndrade, Vanessa Gutierrez-
Autor(es): dc.creatorBraz, Aline Márcia Marques-
Autor(es): dc.creatorWinckler, Fernanda Cristina-
Autor(es): dc.creatorBarbosa, Livia Roma-
Autor(es): dc.creatorGolim, Márjorie de Assis-
Autor(es): dc.creatorSilveira, Liciana Vaz de Arruda-
Autor(es): dc.creatorSimões, Rafael Plana-
Autor(es): dc.creatorSilva, Giovanni Faria-
Data de aceite: dc.date.accessioned2025-08-21T18:41:07Z-
Data de disponibilização: dc.date.available2025-08-21T18:41:07Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10238-021-00749-1-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229261-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229261-
Descrição: dc.descriptionHepatitis C virus has infected over 71 million people worldwide, and it is the main cause of cirrhosis in the western world. Currently, the treatment involves direct-acting antiviral agents (DAAs) and its main goal is to achieve sustained virologic response (SVR). The aim of this study was to evaluate the impact of SVR using DAAs in the improvement of liver fibrosis using scores evaluation by indirect method, liver function, and inflammation indirect biomarkers. Patients with cirrhosis with SVR after treatment (n = 104) were evaluated using liver function scores, indirect fibrosis methods, alpha-fetoprotein, and ferritin at t-base and t-SVR. Statistically significant positive results in all parameters were observed: 54 patients were classified as 5 in the CP score in t-base, and 77 in t-SVR; a significant decrease was observed in MELD score, alpha-fetoprotein, ferritin, APRI, FIB-4 and liver stiffness in liver elastography. We did not observe difference in the liver function scores between regressors and non-regressors of liver stiffness, as well as in indirect inflammation biomarkers. The measurements of fibrosis using the indirect methods have significantly decreased in patients with cirrhosis treated who achieved SVR associated with decreased indirect inflammation biomarkers and improved liver function scores.-
Descrição: dc.descriptionDepartment of Clinical Medicine Botucatu Medical School São Paulo State University (UNESP), Av. Prof. Mário Rubens Guimarães Montenegro, s/n – UNESP-
Descrição: dc.descriptionUndergraduate Course in Medicine Taubaté Medical School - UNITAU-
Descrição: dc.descriptionGraduate Program in Research and Development (Medical Biotechnology) Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Bioestatistics Institute of Biosciences of Botucatu São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Biotechnology and Bioprocess Engineering Faculty of Agronomic Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Clinical Medicine Botucatu Medical School São Paulo State University (UNESP), Av. Prof. Mário Rubens Guimarães Montenegro, s/n – UNESP-
Descrição: dc.descriptionGraduate Program in Research and Development (Medical Biotechnology) Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Bioestatistics Institute of Biosciences of Botucatu São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Biotechnology and Bioprocess Engineering Faculty of Agronomic Sciences São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationClinical and Experimental Medicine-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCirrhosis-
Palavras-chave: dc.subjectDAAs-
Palavras-chave: dc.subjectFibrosis regression-
Palavras-chave: dc.subjectHCV-
Palavras-chave: dc.subjectStiffness-
Título: dc.titleCirrhosis regression after SVR with indirect methods of fibrosis analysis: How far is it real?-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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