Apical periodontitis promotes insulin resistance and alters adaptive immunity markers in rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorSão José do Rio Preto-
Autor(es): dc.creatorFelipe Pereira, Renato-
Autor(es): dc.creatorWillian Lattari Tessarin, Gestter-
Autor(es): dc.creatorYamamoto Chiba, Fernando-
Autor(es): dc.creatorSara de Lima Coutinho Mattera, Maria-
Autor(es): dc.creatorGomes Pereira, Amanda-
Autor(es): dc.creatorVerônica Saori Tsosura, Thais-
Autor(es): dc.creatorGustavo Balera Brito, Victor-
Autor(es): dc.creatorAkira Fujii de Oliveira, Renan-
Autor(es): dc.creatorErvolino, Edilson-
Autor(es): dc.creatorHelena Penha de Oliveira, Sandra-
Autor(es): dc.creatorTavares Angelo Cintra, Luciano-
Autor(es): dc.creatorHissako Matsushita, Doris-
Data de aceite: dc.date.accessioned2025-08-21T17:47:18Z-
Data de disponibilização: dc.date.available2025-08-21T17:47:18Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.sdentj.2021.07.005-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229240-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229240-
Descrição: dc.descriptionObjective: Apical periodontitis (AP) is a chronic or acute inflammatory disease usually developed from endodontic infections, predominantly due to gram-negative anaerobic bacteria invading the dental pulp. This study aimed to evaluate lymphocyte markers to assess the involvement of adaptive immunity in insulin resistance (IR) in a rat model of AP. Design. Forty-five male Wistar albino rats were divided into 3 groups (control, 1AP and 4AP). AP was induced in the upper right first molar (1AP), and in the first and second upper and lower right molars (4AP). The spleen was collected to evaluate the expression of transcription factors involved in lymphocyte polarization, including T-bet (Th1), GATA3 (Th2), and FOXP3 (Treg). Blood samples were assessed for serum cytokine levels transcribed by the respective lymphocyte polarizations, INF-γ (Th1), IL-4 (Th2) and TGF-β (Treg). In addition, glucose and insulin levels were measured to evaluate IR by the HOMA-IR method. Results: The results showed higher T-bet expression on AP groups, along with lower GATA3 and FOXP3 expression in the 1AP, in addition to increased GATA3 and decreased FOXP3 expression in the 4AP group compared to the CN group. There was no difference in the INF-γ levels, while IL-4 was decreased in the AP groups. Taken together, these results suggest that the adaptive immune system, with a predominance of the Th1 polarization, may be involved in the development of IR in rats with AP. Conclusions: AP promotes increase in the expression of T-bet (4AP) and decrease of FOXP3 expressions and IL-4 levels (1AP and 4AP). However, depending on the number of lesions (1 or 4 lesions), the expression of GATA3 appears differently. Thus, innate immunity and adaptive immunity may contribute to the IR observed in rats with AP.-
Descrição: dc.descriptionPrograma de Pós-graduação Multicêntrico em Ciências Fisiológicas PPGMCF SBFis São Paulo State University (UNESP) School of Dentistry-
Descrição: dc.descriptionDepartment of Basic Sciences São Paulo State University (UNESP) School of Dentistry-
Descrição: dc.descriptionUniversity Center North Paulista (UNORP) São José do Rio Preto-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry São Paulo State University (UNESP) School of Dentistry-
Descrição: dc.descriptionMInternal Medicine Department Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Biosciences of Botucatu São Paulo State University (UNESP)-
Descrição: dc.descriptionPrograma de Pós-graduação Multicêntrico em Ciências Fisiológicas PPGMCF SBFis São Paulo State University (UNESP) School of Dentistry-
Descrição: dc.descriptionDepartment of Basic Sciences São Paulo State University (UNESP) School of Dentistry-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry São Paulo State University (UNESP) School of Dentistry-
Descrição: dc.descriptionMInternal Medicine Department Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Biosciences of Botucatu São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationSaudi Dental Journal-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAdaptive immunity-
Palavras-chave: dc.subjectApical periodontitis-
Palavras-chave: dc.subjectEndodontics-
Palavras-chave: dc.subjectInsulin resistance-
Título: dc.titleApical periodontitis promotes insulin resistance and alters adaptive immunity markers in rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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