Effects of multiple sessions of antimicrobial photodynamic therapy (aPDT) in the treatment of periodontitis in patients with uncompensated type 2 diabetes: A randomized controlled clinical study

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorLatin American Institute of Dental Research and Teaching (ILAPEO)-
Autor(es): dc.creatorCláudio, Marina Módolo-
Autor(es): dc.creatorNuernberg, Marta Aparecida Alberton-
Autor(es): dc.creatorRodrigues, João Victor Soares-
Autor(es): dc.creatorBelizário, Lícia Clara Garcia-
Autor(es): dc.creatorBatista, Júlia Arruda-
Autor(es): dc.creatorDuque, Cristiane-
Autor(es): dc.creatorGarcia, Valdir Gouveia-
Autor(es): dc.creatorTheodoro, Letícia Helena-
Data de aceite: dc.date.accessioned2025-08-21T20:34:39Z-
Data de disponibilização: dc.date.available2025-08-21T20:34:39Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.pdpdt.2021.102451-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229231-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229231-
Descrição: dc.descriptionBackground: The aim of this study was to compare, through clinical and microbiological analysis, the use of multiple applications of aPDT as an adjuvant therapy to non-surgical periodontal treatment of stage III and IV grade C periodontitis in type 2 diabetic (DM2) patients. Methods: Thirty-four patients with non-compensated DM2 and periodontitis were randomly divided into two groups: SRP Group (n = 17): scaling and root planing (SRP); and SRP+aPDT Group (n = 17): SRP followed by 3 consecutive aPDT applications, immediately, 48 and 96 h after in pockets with probing depth (PD) ≥5 mm. In SRP+aPDT, after 1 min of irrigation with methylene blue (10 mg/ml), the sites were irradiated with a 660 nm diode laser for 50 s (157 J/cm2, 4.7 J, 100 mW). Porphyromonas gingivalis (P. gingivalis) and Prevotella intermedia (P. intermedia) were quantified by real-time qPCR. Periodontal clinical and microbiological data (baseline, 90 and 180 days) were statistically analyzed (α = 5%). Results: There was a significant reduction in PD and bleeding on probing at 90 and 180 days post-treatment in both groups (p<0.05). The SRP+aPDT group presented a significant reduction in the number of residual pockets at 90 and 180 days (p<0.05). The SRP+aPDT group presented reduced PD means in deep pockets 180 days post-treatment (p<0.05). No differences were observed in P. gingivalis and P. intermedia levels (p>0.05). Conclusion: The results of present study indicate that the use of multiples aPDT sessions as adjuvant therapy in the periodontal treatment of uncompensated diabetic patients with periodontitis promotes additional clinical benefits.-
Descrição: dc.descriptionDepartment of Diagnostic and Surgery Periodontics Division São Paulo State University - UNESP Dentistry School of Araçatuba-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry São Paulo State University - UNESP Dentistry School of Araçatuba-
Descrição: dc.descriptionLatin American Institute of Dental Research and Teaching (ILAPEO)-
Descrição: dc.descriptionDepartment of Diagnostic and Surgery Periodontics Division São Paulo State University - UNESP Dentistry School of Araçatuba-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry São Paulo State University - UNESP Dentistry School of Araçatuba-
Idioma: dc.languageen-
Relação: dc.relationPhotodiagnosis and Photodynamic Therapy-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectclinical trial-
Palavras-chave: dc.subjectDental scaling-
Palavras-chave: dc.subjectDiabetes mellitus type 2-
Palavras-chave: dc.subjectPeriodontitis-
Palavras-chave: dc.subjectPhotodynamic Therapy-
Título: dc.titleEffects of multiple sessions of antimicrobial photodynamic therapy (aPDT) in the treatment of periodontitis in patients with uncompensated type 2 diabetes: A randomized controlled clinical study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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