Focal lymphocytic sialadenitis and ectopic germinal centers in oral reactive lesions and primary Sjögren’s syndrome: a comparative study

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Federal do Rio de Janeiro (UFRJ)-
Autor(es): dc.contributorHospital Herrera-Llerandi/AMEDESGUA-
Autor(es): dc.creatorSilva, Evânio Vilela-
Autor(es): dc.creatorAlmeida, Luciana Yamamoto-
Autor(es): dc.creatorBortoletto, Karen Cristine-
Autor(es): dc.creatorQuero, Isabela Barbosa-
Autor(es): dc.creatorJacomini, Fernanda Carolina-
Autor(es): dc.creatorde Andrade, Bruno Augusto Benevenuto-
Autor(es): dc.creatorSilveira, Heitor Albergoni-
Autor(es): dc.creatorDuarte, Andressa-
Autor(es): dc.creatorPetean, Flávio Calil-
Autor(es): dc.creatorRocha, Eduardo Melani-
Autor(es): dc.creatorRibeiro-Silva, Alfredo-
Autor(es): dc.creatorCarlos, Román-
Autor(es): dc.creatorLeón, Jorge Esquiche-
Data de aceite: dc.date.accessioned2025-08-21T21:49:57Z-
Data de disponibilização: dc.date.available2025-08-21T21:49:57Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00296-021-04949-6-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229187-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229187-
Descrição: dc.descriptionFocal lymphocytic sialadenitis (FLS), an important diagnostic criterion for Sjögren’s syndrome (SS) diagnosis, can also be observed when assessing minor salivary gland (mSG) biopsies from healthy asymptomatic individuals (non-SS patients). Fifty cases of primary SS (pSS group) and 31 cases of oral reactive lesions (non-SS non-sicca group) containing also typical FLS features, were assessed by morphological and immunohistochemical (CD10, CD23 and Bcl-6) analysis, aiming at the detection of GCs. All pSS cases showed FLS with focus score (FS) ≥ 1. In the non-SS non-sicca group, 12, 10 and 9 cases showed FLS with FS ≥ 1, FLS with FS < 1 and FLS associated with chronic sclerosing sialadenitis with FS < 1, respectively. The morphological analysis revealed similar frequency of GCs in pSS (20%) and non-SS non-sicca group (19%). The area (p = 0.052) and largest diameter (p = 0.245) of GCs were higher in pSS than non-SS non-sicca group. The FS and number of foci were significantly higher in pSS than non-SS non-sicca group with FS < 1. Immunohistochemistry confirmed all morphological findings (GCs showing CD23 and Bcl-6 positivity, with variable CD10 expression) and additionally in 3 and 1 cases of the pSS and non-SS non-sicca group, respectively. Moreover, another 6 and 2 cases of the pSS and non-SS non-sicca group with FS ≥ 1, respectively, showed positivity only for CD23. FLS can also be observed when assessing oral reactive lesions, which showed similar frequency of GCs with those found in pSS patients. Further studies, including functional analysis of lymphocytic populations and GCs in FLS, are encouraged.-
Descrição: dc.descriptionOral Medicine Department of Diagnosis and Surgery Araraquara Dental School Sao Paulo State University (UNESP)-
Descrição: dc.descriptionOral Pathology Department of Stomatology Public Oral Health and Forensic Dentistry School of Dentistry of Ribeirão Preto University of São Paulo (FORP/USP)-
Descrição: dc.descriptionOral Pathology Department of Oral Diagnosis and Pathology School of Dentistry Federal University of Rio de Janeiro (UFRJ)-
Descrição: dc.descriptionDepartment of Pathology and Forensic Medicine Ribeirão Preto Medical School (FMRP/USP) University of São Paulo-
Descrição: dc.descriptionDepartment of Ophthalmology Otorhinolaryngology and Head and Neck Surgery Ribeirão Preto Medical School University of São Paulo-
Descrição: dc.descriptionDepartament of Pathology Hospital Herrera-Llerandi/AMEDESGUA-
Descrição: dc.descriptionOral Medicine Department of Diagnosis and Surgery Araraquara Dental School Sao Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationRheumatology International-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEctopic germinal centers-
Palavras-chave: dc.subjectFocal lymphocytic sialadenitis-
Palavras-chave: dc.subjectImmunohistochemistry-
Palavras-chave: dc.subjectNon-Sjögren’s non-sicca patient-
Palavras-chave: dc.subjectOral reactive lesions-
Palavras-chave: dc.subjectSjögren’s syndrome-
Título: dc.titleFocal lymphocytic sialadenitis and ectopic germinal centers in oral reactive lesions and primary Sjögren’s syndrome: a comparative study-
Tipo de arquivo: dc.typelivro digital-
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