Relevance of peroxiredoxins in pathogenic microorganisms

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorde Oliveira, Marcos Antonio-
Autor(es): dc.creatorTairum, Carlos A.-
Autor(es): dc.creatorNetto, Luis Eduardo Soares-
Autor(es): dc.creatorde Oliveira, Ana Laura Pires-
Autor(es): dc.creatorAleixo-Silva, Rogerio Luis-
Autor(es): dc.creatorCabrera, Vitoria Isabela Montanhero-
Autor(es): dc.creatorBreyer, Carlos A.-
Autor(es): dc.creatordos Santos, Melina Cardoso-
Data de aceite: dc.date.accessioned2025-08-21T22:15:37Z-
Data de disponibilização: dc.date.available2025-08-21T22:15:37Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00253-021-11360-5-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229164-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229164-
Descrição: dc.descriptionAbstract: The oxidative and nitrosative responses generated by animals and plants are important defenses against infection and establishment of pathogenic microorganisms such as bacteria, fungi, and protozoa. Among distinct oxidant species, hydroperoxides are a group of chemically diverse compounds that comprise small hydrophilic molecules, such as hydrogen peroxide and peroxynitrite, and bulky hydrophobic species, such as organic hydroperoxides. Peroxiredoxins (Prx) are ubiquitous enzymes that use a highly reactive cysteine residue to decompose hydroperoxides and can also perform other functions, like molecular chaperone and phospholipase activities, contributing to microbial protection against the host defenses. Prx are present in distinct cell compartments and, in some cases, they can be secreted to the extracellular environment. Despite their high abundance, Prx expression can be further increased in response to oxidative stress promoted by host defense systems, by treatment with hydroperoxides or by antibiotics. In consequence, some isoforms have been described as virulence factors, highlighting their importance in pathogenesis. Prx are very diverse and are classified into six different classes (Prx1-AhpC, BCP-PrxQ, Tpx, Prx5, Prx6, and AhpE) based on structural and biochemical features. Some groups are absent in hosts, while others present structural peculiarities that differentiate them from the host’s isoforms. In this context, the intrinsic characteristics of these enzymes may aid the development of new drugs to combat pathogenic microorganisms. Additionally, since some isoforms are also found in the extracellular environment, Prx emerge as attractive targets for the production of diagnostic tests and vaccines. Key points: • Peroxiredoxins are front-line defenses against host oxidative and nitrosative stress. • Functional and structural peculiarities differ pathogen and host enzymes. • Peroxiredoxins are potential targets to microbicidal drugs.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP) Universidade Estadual Paulista Júlio de Mesquita Filho, Campus do Litoral Paulista-
Descrição: dc.descriptionDepartamento de Genética e Biologia Evolutiva Instituto de Biociências Universidade de São Paulo-
Descrição: dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP) Universidade Estadual Paulista Júlio de Mesquita Filho, Campus do Litoral Paulista-
Descrição: dc.descriptionFAPESP: 11/13500-6-
Descrição: dc.descriptionFAPESP: 16/15849-0-
Descrição: dc.descriptionFAPESP: 17/06263-4-
Descrição: dc.descriptionFAPESP: 19/04054-4-
Descrição: dc.descriptionFAPESP: 20/00845-4-
Descrição: dc.descriptionFAPESP: 20/02868-1-
Descrição: dc.descriptionFAPESP: 2013/07937-8-
Descrição: dc.descriptionFAPESP: 2017/19942-7-
Formato: dc.format5701-5717-
Idioma: dc.languageen-
Relação: dc.relationApplied Microbiology and Biotechnology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntibiotic resistance-
Palavras-chave: dc.subjectHydroperoxides-
Palavras-chave: dc.subjectOxidative stress-
Palavras-chave: dc.subjectPeroxiredoxins-
Palavras-chave: dc.subjectStructure-
Palavras-chave: dc.subjectVirulence-
Título: dc.titleRelevance of peroxiredoxins in pathogenic microorganisms-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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