Human papillomavirus co-infection and survival in oral and oropharyngeal squamous cell carcinoma: A study in 235 Brazilian patients

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorCentro Clínico de Cabeza y Cuello-
Autor(es): dc.creatorSilveira, Heitor Albergoni-
Autor(es): dc.creatorAlmeida, Luciana Yamamoto-
Autor(es): dc.creatorCarlos, Roman-
Autor(es): dc.creatorSilva, Evânio Vilela-
Autor(es): dc.creatorFerrisse, Tulio Morandin-
Autor(es): dc.creatorDuarte, Andressa-
Autor(es): dc.creatorCardoso, Suziene Caroline Silva-
Autor(es): dc.creatorPolanco, Xiomara Beatriz Jimenez-
Autor(es): dc.creatorBufalino, Andreia-
Autor(es): dc.creatorRibeiro-Silva, Alfredo-
Autor(es): dc.creatorLeón, Jorge Esquiche-
Data de aceite: dc.date.accessioned2025-08-21T21:05:18Z-
Data de disponibilização: dc.date.available2025-08-21T21:05:18Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.anl.2021.06.006-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229163-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229163-
Descrição: dc.descriptionObjectives: While unknown for oropharyngeal squamous cell carcinoma (OPSCC) and oral squamous cell carcinoma (OSCC), some studies assessing cervical carcinoma have shown that human papillomavirus (HPV) co-infection can be associated with its prognosis. Methods: Through in situ hybridization (HPV and Epstein-Barr virus [EBV] probes) and immunohistochemistry (p16INK4a, cyclin D1, p53, and Ki-67 antibodies), 126 OPSCC and 109 OSCC samples were assessed. Results: All patients were EBV-negative. OPSCC (25%) showed a significant association with HPV compared to OSCC (11%). Almost all HPV-associated cases were p16INK4a-positive. Regarding OPSCC and OSCC, 23 and 7 cases were positive for high-risk HPV (HRHPV) only, 6 and 3 cases for low-risk HPV (LRHPV) only, and 3 and 2 cases for HRHPV/LRHPV, respectively. HPV-associated carcinomas showed a significantly higher proliferative index than HPV-unassociated carcinomas. Both carcinomas showed a similar overall survival rate, which was not affected by the HPV status. However, when comparing HPV-associated subgroups, patients with HRHPV/LRHPV-associated carcinomas showed worse survival. Conclusion: LRHPV-associated and HRHPV/LRHPV-associated cases can also be detected when assessing OSCC and OPSCC. Further studies, especially in populations with a high prevalence of HPV-associated OPSCC, are necessary to understand the clinicopathological behavior of these neoplasm subgroups.-
Descrição: dc.descriptionOral Pathology Department of Stomatology Public Oral Health and Forensic Dentistry Ribeirão Preto Dental School (FORP/USP) University of São Paulo, São Paulo-
Descrição: dc.descriptionOral Medicine Department of Diagnosis and Surgery Araraquara Dental School São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionCentro Clínico de Cabeza y Cuello-
Descrição: dc.descriptionDepartment of Pathology and Forensic Medicine Ribeirão Preto Medical School (FMRP/USP) University of São Paulo, São Paulo-
Descrição: dc.descriptionOral Medicine Department of Diagnosis and Surgery Araraquara Dental School São Paulo State University (UNESP), São Paulo-
Formato: dc.format258-270-
Idioma: dc.languageen-
Relação: dc.relationAuris Nasus Larynx-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectHead and neck squamous cell carcinoma-
Palavras-chave: dc.subjectHigh-risk HPV-
Palavras-chave: dc.subjectIn situ hybridization-
Palavras-chave: dc.subjectLow-risk HPV-
Palavras-chave: dc.subjectOral cavity-
Palavras-chave: dc.subjectOropharynx-
Título: dc.titleHuman papillomavirus co-infection and survival in oral and oropharyngeal squamous cell carcinoma: A study in 235 Brazilian patients-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.