Cytotoxicity and effects of curcumin and cinnamaldehyde hybrids on biofilms of oral pathogens

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorDos Santos, Vanessa Rodrigues-
Autor(es): dc.creatorCaiaffa, Karina Sampaio-
Autor(es): dc.creatorOliveira, Warlley Campos de-
Autor(es): dc.creatorPereira, Jesse Augusto-
Autor(es): dc.creatorAbuna, Gabriel Flores-
Autor(es): dc.creatorPolaquini, Carlos Roberto-
Autor(es): dc.creatorRegasini, Luís Octávio-
Autor(es): dc.creatorGuiotti, Aimée Maria-
Autor(es): dc.creatorDuque, Cristiane-
Data de aceite: dc.date.accessioned2025-08-21T17:17:58Z-
Data de disponibilização: dc.date.available2025-08-21T17:17:58Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/08927014.2021.1942859-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229102-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229102-
Descrição: dc.descriptionThe objective of the study was to evaluate the cytotoxicity and effect of curcumin-cinnamaldehyde hybrids (CCHs) on the biofilm of oral pathogens. Of the 18 hybrids tested, nine had an inhibitory effect on at least one of the bacterial species tested, with minimal inhibitory and bactericidal concentrations ranging from 9 to 625 μg ml−1. CCH 7 promoted a potent inhibitory effect against all the bacterial species tested and better compatibility than chlorhexidine (CHX). CCH 7 also presented a similar or improved effect over that of CHX, causing a reduction in bacterial metabolism and viability in single and dual-species biofilms. CCH 7 reduced by 86% and 34% the viability of multispecies biofilms formed by collection and clinical strains. It can be concluded that CCH 7 was cytocompatible at the minimal inhibitory concentration, presented anti-biofilm action against oral pathogens, and could act as an antimicrobial agent for application in endodontics.-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry Araçatuba School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Restorative Dentistry Faculty of Dentistry of Piracicaba University of Campinas (UNICAMP)-
Descrição: dc.descriptionDepartment of Chemistry and Environmental Sciences Institute of Biosciences Humanities and Exact Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics Araçatuba School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry Araçatuba School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Chemistry and Environmental Sciences Institute of Biosciences Humanities and Exact Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics Araçatuba School of Dentistry São Paulo State University (UNESP)-
Formato: dc.format591-605-
Idioma: dc.languageen-
Relação: dc.relationBiofouling-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantimicrobial activity-
Palavras-chave: dc.subjectbiofilm-
Palavras-chave: dc.subjectcinnamaldehyde-
Palavras-chave: dc.subjectCurcumin-
Palavras-chave: dc.subjectcytotoxicity-
Título: dc.titleCytotoxicity and effects of curcumin and cinnamaldehyde hybrids on biofilms of oral pathogens-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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