Analysis of permeability and biological properties of dentin treated with experimental bioactive glasses

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFaculty of Dentistry-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.creatorReis, Bruna de Oliveira-
Autor(es): dc.creatorPrakki, Anuradha-
Autor(es): dc.creatorStavroullakis, Alexander Terry-
Autor(es): dc.creatorSouza, Marina Trevelin-
Autor(es): dc.creatorSiqueira, Renato Luiz-
Autor(es): dc.creatorZanotto, Edgar Dutra-
Autor(es): dc.creatorBriso, André Luiz Fraga-
Autor(es): dc.creatorTavares Ângelo Cintra, Luciano-
Autor(es): dc.creatorHenrique dos Santos, Paulo-
Data de aceite: dc.date.accessioned2025-08-21T17:20:22Z-
Data de disponibilização: dc.date.available2025-08-21T17:20:22Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jdent.2021.103719-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229080-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229080-
Descrição: dc.descriptionObjectives: To evaluate obliterating capability and biological performance of desensitizing agents. Methods: 50 dentin blocks were distributed according to the desensitizing agent used (n = 10): Control (Artificial saliva); Ultra EZ (Ultradent); Desensibilize Nano P (FGM); T5-OH Bioactive Glass (Experimental solution); F18 Bioactive Glass (Experimental solution). Desensitizing treatments were performed for 15 days. In addition, specimens were subjected to acid challenge to simulate oral environment demineralizing conditions. Samples were subjected to permeability analysis before and after desensitizing procedures and acid challenge. Cytotoxicity analysis was performed by using Alamar Blue assay and complemented by total protein quantification by Pierce Bicinchoninic Acid assay at 15 min, 24-h and 48-h time points. Scanning electron microscopy and energy dispersion X-ray spectroscopy were performed for qualitative analysis. Data of dentin permeability was analyzed by two-way repeated measures ANOVA and Tukey's test. For cytotoxicity, Kruskal-Wallis and Newman-Keuls tests. Results: for dentin permeability there was no significant difference among desensitizing agents after treatment, but control group presented highest values (0.131 ± 0.076 Lp). After acid challenge, control group maintained highest values (0.044 ± 0.014 Lp) with significant difference to other groups, except for Desensibilize Nano P (0.037 ± 0.019 Lp). For cytotoxicity, there were no significant differences among groups. Conclusion: Bioglass-based desensitizers caused similar effects to commercially available products, regarding permeability and dentin biological properties. Clinical significance: There is no gold standard protocol for dentin sensitivity. The study of novel desensitizing agents that can obliterate dentinal tubules in a faster-acting and long-lasting way may help meet this clinical need.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Dentistry Araçatuba Department of Preventive and Restorative Dentistry, 1193 José Bonifácio St.16015-050 Araçatuba-
Descrição: dc.descriptionUniversity of Toronto Faculty of Dentistry Department of Restorative Dentistry, RM 537124 Edward St.-
Descrição: dc.descriptionFederal University of São Carlos (UFSCar) Department of Materials Engineering Vitreous Materials Laboratory (LaMaV) CP. 676, 13565-905-
Descrição: dc.descriptionProfessor São Paulo State University (UNESP) School of Dentistry Araçatuba Department of Dental Materials and Prosthodontics, 1193 José Bonifácio St.16015-050 Araçatuba-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Dentistry Araçatuba Department of Preventive and Restorative Dentistry, 1193 José Bonifácio St.16015-050 Araçatuba-
Descrição: dc.descriptionProfessor São Paulo State University (UNESP) School of Dentistry Araçatuba Department of Dental Materials and Prosthodontics, 1193 José Bonifácio St.16015-050 Araçatuba-
Descrição: dc.descriptionCAPES: 88887.363216/2019-00-
Idioma: dc.languageen-
Relação: dc.relationJournal of Dentistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCell biology-
Palavras-chave: dc.subjectDentin permeability-
Palavras-chave: dc.subjectDentin sensitivity-
Palavras-chave: dc.subjectDesensitizing agents-
Título: dc.titleAnalysis of permeability and biological properties of dentin treated with experimental bioactive glasses-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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