Regulatory T cells and vaccine effectiveness in older adults. Challenges and prospects

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorMaimonides Institute for Biomedical Research of Cordoba (IMIBIC)-
Autor(es): dc.contributorUniversity of Valencia-
Autor(es): dc.contributorUniversity of Córdoba-
Autor(es): dc.contributorReina Sofia University Hospital-
Autor(es): dc.creatorBatista-Duharte, Alexander-
Autor(es): dc.creatorPera, Alejandra-
Autor(es): dc.creatorAliño, Salvador F.-
Autor(es): dc.creatorSolana, Rafael-
Data de aceite: dc.date.accessioned2025-08-21T19:08:05Z-
Data de disponibilização: dc.date.available2025-08-21T19:08:05Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2021-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.intimp.2021.107761-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229063-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229063-
Descrição: dc.descriptionSince the discovery of lymphocytes with immunosuppressive activity, increasing interest has arisen in their possible influence on the immune response induced by vaccines. Regulatory T cells (Tregs) are essential for maintaining peripheral tolerance, preventing autoimmune diseases, and limiting chronic inflammatory diseases. However, they also limit beneficial immune responses by suppressing anti-infectious and anti-tumor immunity. Mounting evidence suggests that Tregs are involved, at least in part, in the low effectiveness of immunization against various diseases where it has been difficult to obtain protective vaccines. Interestingly, increased activity of Tregs is associated with aging, suggesting a key role for these cells in the lower vaccine effectiveness observed in older people. In this review, we analyze the impact of Tregs on vaccination, with a focus on older adults. Finally, we address an overview of current strategies for Tregs modulation with potential application to improve the effectiveness of future vaccines targeting older populations.-
Descrição: dc.descriptionDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University (UNESP), Rod. Araraquara-Jaú - Km 1-
Descrição: dc.descriptionImmunology and Allergy Group Maimonides Institute for Biomedical Research of Cordoba (IMIBIC)-
Descrição: dc.descriptionDepartment of Pharmacology Medicine Faculty University of Valencia-
Descrição: dc.descriptionDepartment of Cell Biology Physiology and Immunology University of Córdoba-
Descrição: dc.descriptionImmunology and Allergy Service Reina Sofia University Hospital-
Descrição: dc.descriptionDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University (UNESP), Rod. Araraquara-Jaú - Km 1-
Idioma: dc.languageen-
Relação: dc.relationInternational Immunopharmacology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAdjuvants-
Palavras-chave: dc.subjectImmune response-
Palavras-chave: dc.subjectImmunosenescense-
Palavras-chave: dc.subjectOlder adults-
Palavras-chave: dc.subjectRegulatory T cells-
Palavras-chave: dc.subjectSARS-CoV-2-
Palavras-chave: dc.subjectVaccine-
Título: dc.titleRegulatory T cells and vaccine effectiveness in older adults. Challenges and prospects-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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