Thiopurines: Use them or lose them? International survey on current and future use of thiopurines in inflammatory bowel disease

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorTondela-Viseu Hospital Centre-
Autor(es): dc.contributorUniversita Cattolica-
Autor(es): dc.contributorGoethe-University-
Autor(es): dc.contributorOslo University Hospital-
Autor(es): dc.contributorHospital Clínico Universitario de Santiago de Compostela-
Autor(es): dc.contributorUniversity Hospital-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorCatholic University of Paraná (PUCPR)-
Autor(es): dc.contributorUniversity of Lorraine-
Autor(es): dc.contributorUniversity of Porto-
Autor(es): dc.contributorSão João University Hospital-
Autor(es): dc.contributorCentre for Drug Discovery and Innovative Medicines-
Autor(es): dc.creatorSousa, Paula-
Autor(es): dc.creatorMinistro, Paula-
Autor(es): dc.creatorArmuzzi, Alessandro-
Autor(es): dc.creatorDignass, Axel-
Autor(es): dc.creatorHøivik, Marte Lie-
Autor(es): dc.creatorBarreiro-de Acosta, Manuel-
Autor(es): dc.creatorVavricka, Stephan-
Autor(es): dc.creatorSaad-Hossne, Rogério-
Autor(es): dc.creatorGustavo Kotze, Paulo-
Autor(es): dc.creatorPeyrin-Biroulet, Laurent-
Autor(es): dc.creatorMagro, Fernando-
Data de aceite: dc.date.accessioned2025-08-21T17:33:27Z-
Data de disponibilização: dc.date.available2025-08-21T17:33:27Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.dld.2021.05.038-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229052-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229052-
Descrição: dc.descriptionBackground and aims: The role of thiopurines in therapeutic algorithms of Crohn's disease (CD) and Ulcerative colitis (UC) is being questioned. This work aimed to investigate current practice and future perspectives of Inflammatory Bowel Disease (IBD) physicians regarding the efficacy, safety, and role of precision medicine with thiopurines in IBD. Methods: A 29-questions web-based survey was developed and distributed to IBD physicians worldwide. Results: We collected the complete answers of 408 physicians from 50 countries. Most participants were experienced physicians in IBD; 26.0% met our definition of “IBD expert”. Four physicians reported to not use thiopurines in clinical practice. Most respondents used thiopurines in monotherapy and in combination therapy, both in CD and UC. Respondents tended to consider thiopurines as drugs with a good safety profile, with the agreement of 61.5% of the overall cohort. A minority of physicians (~6%) considered that thiopurines will not be used in the future in IBD patients, while 57.8% believed that these drugs will still be used, in mono and combination therapy. Conclusion: Despite the many emerging treatments in IBD, according to the beliefs of most physicians surveyed, thiopurines will still be an important part of the treatment algorithm of both CD and UC.-
Descrição: dc.descriptionDepartment of Gastroenterology Viseu Unit Tondela-Viseu Hospital Centre-
Descrição: dc.descriptionIBD Center Fondazione Policlinico Universitario A. Gemelli IRCCS Universita Cattolica-
Descrição: dc.descriptionDepartment of Medicine I Agaplesion Markus Hospital Goethe-University-
Descrição: dc.descriptionDepartment of Gastroenterology Oslo University Hospital-
Descrição: dc.descriptionIBD Unit Department of Gastroenterology Hospital Clínico Universitario de Santiago de Compostela-
Descrição: dc.descriptionDivision of Gastroenterology and Hepatology University Hospital-
Descrição: dc.descriptionDepartment of Internal Medicine São Paulo State University (Unesp) Medical School-
Descrição: dc.descriptionColorectal Surgery Unit IBD outpatient clinics Catholic University of Paraná (PUCPR)-
Descrição: dc.descriptionDepartment of Gastroenterology and Inserm NGERE U1256 University Hospital of Nancy University of Lorraine-
Descrição: dc.descriptionDepartment of Biomedicine Unit of Pharmacology and Therapeutics University of Porto-
Descrição: dc.descriptionDepartment of Gastroenterology São João University Hospital-
Descrição: dc.descriptionMedInUP Centre for Drug Discovery and Innovative Medicines-
Descrição: dc.descriptionDepartment of Internal Medicine São Paulo State University (Unesp) Medical School-
Idioma: dc.languageen-
Relação: dc.relationDigestive and Liver Disease-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCrohn's disease-
Palavras-chave: dc.subjectInflammatory bowel disease-
Palavras-chave: dc.subjectPrecision medicine-
Palavras-chave: dc.subjectThiopurines-
Palavras-chave: dc.subjectUlcerative colitis-
Título: dc.titleThiopurines: Use them or lose them? International survey on current and future use of thiopurines in inflammatory bowel disease-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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