Evaluation of the effectiveness of antenatal corticoid in preterm twin and single pregnancies: a multicenter cohort study

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorFernandes Figueira Institute-
Autor(es): dc.contributorPorto Alegre Clinic Hospital-
Autor(es): dc.contributorRio de Janeiro State University-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorFaculty of Medical Sciences of Minas Gerais-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorSão Paulo Federal University-
Autor(es): dc.contributorUniversidade Estadual de Londrina (UEL)-
Autor(es): dc.contributorFederal University of Parana-
Autor(es): dc.contributorProfessor Fernando Figueira Institute of Integral Medicine-
Autor(es): dc.contributorUniversity Hospital of the Federal University of Maranhão-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorPontifical Catholic University of Rio Grande do Sul-
Autor(es): dc.creatorAssad Gonçalves-Ferri, Walusa-
Autor(es): dc.creatorMartinez, Francisco Eulógio-
Autor(es): dc.creatorMartins-Celini, Fábia Pereira-
Autor(es): dc.creatorde Almeida, João Henrique Carvalho Leme-
Autor(es): dc.creatorProcianoy, Renato-
Autor(es): dc.creatorDuarte, José Luiz Muniz Bandeira-
Autor(es): dc.creatorCarvalho, Elaine Alvarenga Almeida-
Autor(es): dc.creatorde Lima Mota Ferreira, Daniela Marques-
Autor(es): dc.creatorAlves Filho, Navantino-
Autor(es): dc.creatorSantos, Juliana Paula-
Autor(es): dc.creatorGimenez, Carolina Boschi-
Autor(es): dc.creatordo Santos, Cristina Nunes-
Autor(es): dc.creatorFerrari, Ligia S. Lopes-
Autor(es): dc.creatorVenzon, Paulyne Stadler-
Autor(es): dc.creatorMeneses, Jucille-
Autor(es): dc.creatordo Vale, Marynéa Silva-
Autor(es): dc.creatorde Souza Rugolo, Ligia Maria Suppo-
Autor(es): dc.creatorde Almeida, Maria Fernando Branco-
Autor(es): dc.creatorKrebs, Vera Lucia Jornada-
Autor(es): dc.creatorde Albuquerque Diniz, Edna Maria-
Autor(es): dc.creatorFiori, Humberto Holmer-
Autor(es): dc.creatorMarba, Sergio Tadeu Martins-
Data de aceite: dc.date.accessioned2025-08-21T20:29:51Z-
Data de disponibilização: dc.date.available2025-08-21T20:29:51Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/14767058.2020.1822806-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229011-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229011-
Descrição: dc.descriptionBackground: The effects of antenatal corticosteroids (ANSs) on twins are not well established. Objective: To determine the impact of ANS use according to the number of fetuses. Methods: Retrospective cohort study of newborns between 23 and 33 weeks of gestational age, birth weight from 400 to 1499 g, without malformations, delivered at 20 public university hospitals from 2010 to 2014. Exposed group: Received ANS (any time, any dose) and no exposed group: no received ANS. Analysis of birth conditions and clinical outcomes. Association of variables, relative risks, and 95% confidence intervals estimated from the adjustment of log-binomial regression models. Results: About 7165 premature infants were analyzed: 5167 singleton, 937 twins, and 104 triplets. Characteristics of gestations with one, two, or three fetuses not receiving ANS were similar. Reduced hemodynamic instability in single and twins gestations in the first 72 h were observed (Adj R 2 Twins = 0.78; 95% CI = 0.69–0.86) (Adj R 2 Singles = 0.79; 95% CI = 0.62–0.99). Reduced peri-intraventricular hemorrhage (Adj R 2 Twins = 0.54; 95% CI = 0.36–0.78) (Adj R 2 singles = 0.54; 95% CI = 0.36–0.78); and early sepsis reduction on single and triplex gestations (Adj R 2 triplex = 0.51; 95% CI = 0.27–0.94) (Adj single R 2 = 0.51; 95% CI = 0.27–0.94) were observed. Conclusions: This study demonstrates ANS produces an important protective factor for severe intraventricular hemorrhage and hemodynamic instability in single and multiple pregnancies. ANS had a protective effect on death and birth conditions improvement just in single gestations. Regarding respiratory aspects was not observed the protective effect in the single or multiple gestations.-
Descrição: dc.descriptionDepartment of Pediatrics Ribeirão Preto Medical School University of São Paulo-
Descrição: dc.descriptionDepartment of Pediatrics Oswaldo Cruz Foundation Fernandes Figueira Institute-
Descrição: dc.descriptionDepartment of Pediatrics Federal University of Rio Grande do Sul Porto Alegre Clinic Hospital-
Descrição: dc.descriptionDepartment of Pediatrics Universitary Hospital Pedro Rio de Janeiro State University-
Descrição: dc.descriptionDepartment of Pediatrics Federal University of Minas Gerais-
Descrição: dc.descriptionDepartment of Pediatrics Federal University of Uberlandia-
Descrição: dc.descriptionDepartment of Pediatrics Faculty of Medical Sciences of Minas Gerais-
Descrição: dc.descriptionDepartment of Pediatrics Sumare State Hospital State University of Campinas-
Descrição: dc.descriptionPirajussara State Hospital Department of Pediatrics Federal University of São Paulo-
Descrição: dc.descriptionState Hospital Diadema Neonatal Unit São Paulo Federal University-
Descrição: dc.descriptionDepartment of Pediatrics Londrina State University Health Sciences Center-
Descrição: dc.descriptionDepartment of Pediatrics Federal University of Parana-
Descrição: dc.descriptionDepartment of Pediatrics Professor Fernando Figueira Institute of Integral Medicine-
Descrição: dc.descriptionDepartment of Pediatrics University Hospital of the Federal University of Maranhão-
Descrição: dc.descriptionDepartment of Pediatrics Botucatu Medical School- São Paulo State University Julio de Mesquita Neto-
Descrição: dc.descriptionDepartment of Pediatrics Federal University of São Paulo-
Descrição: dc.descriptionDepartment of Pediatrics Children’s Institute São Paulo Medical School University of São Paulo-
Descrição: dc.descriptionDepartment of Pediatrics University Hospital São Paulo Medical School University of São Paulo-
Descrição: dc.descriptionDepartment of Pediatrics Pontifical Catholic University of Rio Grande do Sul-
Descrição: dc.descriptionDepartment of Pediatrics Campinas State University-
Descrição: dc.descriptionDepartment of Pediatrics Botucatu Medical School- São Paulo State University Julio de Mesquita Neto-
Idioma: dc.languageen-
Relação: dc.relationJournal of Maternal-Fetal and Neonatal Medicine-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantenatal corticoid-
Palavras-chave: dc.subjectmultiple births-
Palavras-chave: dc.subjectneonatology-
Palavras-chave: dc.subjectneurology-
Palavras-chave: dc.subjectTwins-
Título: dc.titleEvaluation of the effectiveness of antenatal corticoid in preterm twin and single pregnancies: a multicenter cohort study-
Tipo de arquivo: dc.typelivro digital-
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