Randomized, double-blind, placebo-controlled split-face trial of the efficacy of tranexamic acid by drug delivery through microneedling in the treatment of melasma

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorHospital Universitário Evangélico Mackenzie-
Autor(es): dc.creatorKuster Kaminski Arida, Dâmia-
Autor(es): dc.creatorOrso Rebellato, Priscila Regina-
Autor(es): dc.creatorMarioto de Campos, Giovana Liz-
Autor(es): dc.creatorCosta, Adriane-
Autor(es): dc.creatorVilaverde Schmitt, Juliano-
Autor(es): dc.creatorLarocca Skare, Thelma-
Autor(es): dc.creatorRodrigues Lisboa Faucz, Luciana-
Data de aceite: dc.date.accessioned2025-08-21T18:43:02Z-
Data de disponibilização: dc.date.available2025-08-21T18:43:02Z-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/jocd.14257-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/229002-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/229002-
Descrição: dc.descriptionBackground: Melasma is a prevalent skin pigmentation disorder that is difficult to treat. Tranexamic acid (TA) is a potential agent, but there are few studies on its effectiveness under the transdermal route (drug delivery—Dd). One of these Dd pathways is through microneedling, which seems to be effective itself. Objective: To evaluate the efficacy of tranexamic acid when applied in the form of drug delivery through microneedling in the treatment of facial melasma. Methods: A randomized controlled double-blind split-face trial with 3 monthly sessions in 20 melasma patients: microneedling was performed in the entire face, and then TA solution was applied to one hemiface and placebo to the other. The effectiveness was measured using Hemi-MASI (Melasma Area and Severity Index), images pixels, and perceptions of experts and patients. Results: Hemi-MASI regressed 22% in control and 29% in TA side. A good/better improvement was found in 37.5% of the control and 42.5% of TA by the experts and 60% of the patients for both sides. Pixels increased by 5 and 7, respectively. In none of these criteria, there was a significant difference between the sides. Conclusion: Tranexamic acid in drug delivery through microneedling did not bring additional benefit to the treatment of melisma.-
Descrição: dc.descriptionDepartment of Dermatology of Hospital Universitário Evangélico Mackenzie-
Descrição: dc.descriptionDepartment of Dermatology of Universidade Estadual Paulista Júlio de Mesquita Filho-
Descrição: dc.descriptionAdvisor of Graduate Program of Instituto de Pesquisas Médicas (IPEM) Hospital Universitário Evangélico Mackenzie-
Descrição: dc.descriptionDepartment of Dermatology of Universidade Estadual Paulista Júlio de Mesquita Filho-
Idioma: dc.languageen-
Relação: dc.relationJournal of Cosmetic Dermatology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectdrug delivery-
Palavras-chave: dc.subjectmelasma-
Palavras-chave: dc.subjectmicroneedling-
Palavras-chave: dc.subjectrandomized controlled trial-
Palavras-chave: dc.subjecttranexamic acid-
Título: dc.titleRandomized, double-blind, placebo-controlled split-face trial of the efficacy of tranexamic acid by drug delivery through microneedling in the treatment of melasma-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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